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Monkeypox Virus Infections in Southern Italy: Is There a Risk for Community Spread?

The ongoing outbreak of the Monkeypox virus (MPXV) is characterized by sustained human-to-human transmission, particularly among men who have sex with men (MSM). The aim of the study was to describe the characteristics of the MPXV infection identified in Southern Italy. Clinical samples for each sus...

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Autores principales: Loconsole, Daniela, Sallustio, Anna, Centrone, Francesca, Casulli, Daniele, Accogli, Marisa, Saracino, Annalisa, Foti, Caterina, Grandolfo, Mauro, Buccoliero, Giovanni Battista, Vitale, Viviana, De Nitto, Sara, Conversano, Michele, Desiante, Francesco, Del Sambro, Laura, Simone, Domenico, Parisi, Antonio, Prato, Rosa, Martinelli, Domenico, Chironna, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517482/
https://www.ncbi.nlm.nih.gov/pubmed/36141993
http://dx.doi.org/10.3390/ijerph191811719
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author Loconsole, Daniela
Sallustio, Anna
Centrone, Francesca
Casulli, Daniele
Accogli, Marisa
Saracino, Annalisa
Foti, Caterina
Grandolfo, Mauro
Buccoliero, Giovanni Battista
Vitale, Viviana
De Nitto, Sara
Conversano, Michele
Desiante, Francesco
Del Sambro, Laura
Simone, Domenico
Parisi, Antonio
Prato, Rosa
Martinelli, Domenico
Chironna, Maria
author_facet Loconsole, Daniela
Sallustio, Anna
Centrone, Francesca
Casulli, Daniele
Accogli, Marisa
Saracino, Annalisa
Foti, Caterina
Grandolfo, Mauro
Buccoliero, Giovanni Battista
Vitale, Viviana
De Nitto, Sara
Conversano, Michele
Desiante, Francesco
Del Sambro, Laura
Simone, Domenico
Parisi, Antonio
Prato, Rosa
Martinelli, Domenico
Chironna, Maria
author_sort Loconsole, Daniela
collection PubMed
description The ongoing outbreak of the Monkeypox virus (MPXV) is characterized by sustained human-to-human transmission, particularly among men who have sex with men (MSM). The aim of the study was to describe the characteristics of the MPXV infection identified in Southern Italy. Clinical samples for each suspected case identified from 1 June to 1 August 2022 were tested for MPXV, and whole-genome sequencing (WGS) was performed on two strains. Ten cases were identified: eight were young adult males, including six MSMs, and two were female. Nine subjects reported recent sexual exposure. One female subject without sexual exposure only reported attendance at a social gathering. Overall, 7 of 10 skin lesion samples had a high viral load of MPXV DNA, and 6/9 whole blood samples and 6/8 nasopharyngeal swab samples also tested positive. The analyzed sequences belonged to Clade 3, lineage B.1, and B.1.5, respectively. Despite this recent multinational outbreak of MPXV cases having revealed a high proportion of cases occurring among MSM, the identification of cases among heterosexual subjects and in a female subject without sexual risk factors should raise awareness among clinicians about the possible spread of MPXV in the general population.
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spelling pubmed-95174822022-09-29 Monkeypox Virus Infections in Southern Italy: Is There a Risk for Community Spread? Loconsole, Daniela Sallustio, Anna Centrone, Francesca Casulli, Daniele Accogli, Marisa Saracino, Annalisa Foti, Caterina Grandolfo, Mauro Buccoliero, Giovanni Battista Vitale, Viviana De Nitto, Sara Conversano, Michele Desiante, Francesco Del Sambro, Laura Simone, Domenico Parisi, Antonio Prato, Rosa Martinelli, Domenico Chironna, Maria Int J Environ Res Public Health Article The ongoing outbreak of the Monkeypox virus (MPXV) is characterized by sustained human-to-human transmission, particularly among men who have sex with men (MSM). The aim of the study was to describe the characteristics of the MPXV infection identified in Southern Italy. Clinical samples for each suspected case identified from 1 June to 1 August 2022 were tested for MPXV, and whole-genome sequencing (WGS) was performed on two strains. Ten cases were identified: eight were young adult males, including six MSMs, and two were female. Nine subjects reported recent sexual exposure. One female subject without sexual exposure only reported attendance at a social gathering. Overall, 7 of 10 skin lesion samples had a high viral load of MPXV DNA, and 6/9 whole blood samples and 6/8 nasopharyngeal swab samples also tested positive. The analyzed sequences belonged to Clade 3, lineage B.1, and B.1.5, respectively. Despite this recent multinational outbreak of MPXV cases having revealed a high proportion of cases occurring among MSM, the identification of cases among heterosexual subjects and in a female subject without sexual risk factors should raise awareness among clinicians about the possible spread of MPXV in the general population. MDPI 2022-09-17 /pmc/articles/PMC9517482/ /pubmed/36141993 http://dx.doi.org/10.3390/ijerph191811719 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Loconsole, Daniela
Sallustio, Anna
Centrone, Francesca
Casulli, Daniele
Accogli, Marisa
Saracino, Annalisa
Foti, Caterina
Grandolfo, Mauro
Buccoliero, Giovanni Battista
Vitale, Viviana
De Nitto, Sara
Conversano, Michele
Desiante, Francesco
Del Sambro, Laura
Simone, Domenico
Parisi, Antonio
Prato, Rosa
Martinelli, Domenico
Chironna, Maria
Monkeypox Virus Infections in Southern Italy: Is There a Risk for Community Spread?
title Monkeypox Virus Infections in Southern Italy: Is There a Risk for Community Spread?
title_full Monkeypox Virus Infections in Southern Italy: Is There a Risk for Community Spread?
title_fullStr Monkeypox Virus Infections in Southern Italy: Is There a Risk for Community Spread?
title_full_unstemmed Monkeypox Virus Infections in Southern Italy: Is There a Risk for Community Spread?
title_short Monkeypox Virus Infections in Southern Italy: Is There a Risk for Community Spread?
title_sort monkeypox virus infections in southern italy: is there a risk for community spread?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517482/
https://www.ncbi.nlm.nih.gov/pubmed/36141993
http://dx.doi.org/10.3390/ijerph191811719
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