Atypical Hemolytic Uremic Syndrome after SARS-CoV-2 Infection: Report of Two Cases

Atypical hemolytic uremic syndrome (aHUS) is a life-threatening disease causing systemic thrombotic microangiopathy (TMA) due to the fact of complement dysregulation. Immune activation by viruses, including SARS-CoV-2, can lead to the development of an episode of aHUS against a background of genetic...

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Autores principales: Smarz-Widelska, Iwona, Syroka-Główka, Małgorzata, Janowska-Jaremek, Joanna, Kozioł, Małgorzata M., Załuska, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517572/
https://www.ncbi.nlm.nih.gov/pubmed/36141710
http://dx.doi.org/10.3390/ijerph191811437
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author Smarz-Widelska, Iwona
Syroka-Główka, Małgorzata
Janowska-Jaremek, Joanna
Kozioł, Małgorzata M.
Załuska, Wojciech
author_facet Smarz-Widelska, Iwona
Syroka-Główka, Małgorzata
Janowska-Jaremek, Joanna
Kozioł, Małgorzata M.
Załuska, Wojciech
author_sort Smarz-Widelska, Iwona
collection PubMed
description Atypical hemolytic uremic syndrome (aHUS) is a life-threatening disease causing systemic thrombotic microangiopathy (TMA) due to the fact of complement dysregulation. Immune activation by viruses, including SARS-CoV-2, can lead to the development of an episode of aHUS against a background of genetic dysregulation in the complement pathway. This paper presents an analysis of two cases of aHUS—siblings diagnosed with familial disease, with a genetic predisposition to aHUS, in whom infection with SARS-CoV-2 was a strong trigger of disease recurrence. The quick recognition and treatment with eculizumab in the early stage of the disease resulted in a rapid improvement in clinical conditions and laboratory parameters.
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spelling pubmed-95175722022-09-29 Atypical Hemolytic Uremic Syndrome after SARS-CoV-2 Infection: Report of Two Cases Smarz-Widelska, Iwona Syroka-Główka, Małgorzata Janowska-Jaremek, Joanna Kozioł, Małgorzata M. Załuska, Wojciech Int J Environ Res Public Health Case Report Atypical hemolytic uremic syndrome (aHUS) is a life-threatening disease causing systemic thrombotic microangiopathy (TMA) due to the fact of complement dysregulation. Immune activation by viruses, including SARS-CoV-2, can lead to the development of an episode of aHUS against a background of genetic dysregulation in the complement pathway. This paper presents an analysis of two cases of aHUS—siblings diagnosed with familial disease, with a genetic predisposition to aHUS, in whom infection with SARS-CoV-2 was a strong trigger of disease recurrence. The quick recognition and treatment with eculizumab in the early stage of the disease resulted in a rapid improvement in clinical conditions and laboratory parameters. MDPI 2022-09-11 /pmc/articles/PMC9517572/ /pubmed/36141710 http://dx.doi.org/10.3390/ijerph191811437 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Smarz-Widelska, Iwona
Syroka-Główka, Małgorzata
Janowska-Jaremek, Joanna
Kozioł, Małgorzata M.
Załuska, Wojciech
Atypical Hemolytic Uremic Syndrome after SARS-CoV-2 Infection: Report of Two Cases
title Atypical Hemolytic Uremic Syndrome after SARS-CoV-2 Infection: Report of Two Cases
title_full Atypical Hemolytic Uremic Syndrome after SARS-CoV-2 Infection: Report of Two Cases
title_fullStr Atypical Hemolytic Uremic Syndrome after SARS-CoV-2 Infection: Report of Two Cases
title_full_unstemmed Atypical Hemolytic Uremic Syndrome after SARS-CoV-2 Infection: Report of Two Cases
title_short Atypical Hemolytic Uremic Syndrome after SARS-CoV-2 Infection: Report of Two Cases
title_sort atypical hemolytic uremic syndrome after sars-cov-2 infection: report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517572/
https://www.ncbi.nlm.nih.gov/pubmed/36141710
http://dx.doi.org/10.3390/ijerph191811437
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