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Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis
At present, ambient air pollution poses a significant threat to patients with cardiovascular disease (CVD). The heart rate variability (HRV) is a marker of the cardiac autonomic nervous system, and it is related to air pollution and cardiovascular disease. There is, however, considerable disagreemen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517606/ https://www.ncbi.nlm.nih.gov/pubmed/36141453 http://dx.doi.org/10.3390/ijerph191811186 |
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author | Zong, Zhiqiang Zhang, Mengyue Xu, Kexin Zhang, Yunquan Hu, Chengyang |
author_facet | Zong, Zhiqiang Zhang, Mengyue Xu, Kexin Zhang, Yunquan Hu, Chengyang |
author_sort | Zong, Zhiqiang |
collection | PubMed |
description | At present, ambient air pollution poses a significant threat to patients with cardiovascular disease (CVD). The heart rate variability (HRV) is a marker of the cardiac autonomic nervous system, and it is related to air pollution and cardiovascular disease. There is, however, considerable disagreement in the literature regarding the association between ozone (O(3)) and HRV. To further investigate the effects of short-term exposure to O(3) on HRV, we conducted the first meta-analysis of relevant studies. The percentage change of HRV indicator(s) is the effect estimate extracted for the quantitative analysis in this study. In our meta-analysis, per 10 ppb increase in O(3) was significantly associated with decreases in the time-domain measurements, for standard deviation of the normal-to-normal (NN) interval (SDNN) −1.11% (95%CI: −1.35%, −0.87%) and for root mean square of successive differences (RMSSD) −3.26% (95%CI: −5.42%, −1.09%); in the frequency-domain measurements, for high frequency (HF) −3.01% (95%CI: −4.66%, −1.35%) and for low frequency (LF) −2.14% (95%CI: −3.83%, −0.45%). This study showed short-term exposure to O(3) was associated with reduced HRV indicators in adults, which suggested that the cardiac autonomic nervous system might be affected after O(3) exposure, contributing to the association between O(3) exposure and CVD risk. |
format | Online Article Text |
id | pubmed-9517606 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95176062022-09-29 Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis Zong, Zhiqiang Zhang, Mengyue Xu, Kexin Zhang, Yunquan Hu, Chengyang Int J Environ Res Public Health Article At present, ambient air pollution poses a significant threat to patients with cardiovascular disease (CVD). The heart rate variability (HRV) is a marker of the cardiac autonomic nervous system, and it is related to air pollution and cardiovascular disease. There is, however, considerable disagreement in the literature regarding the association between ozone (O(3)) and HRV. To further investigate the effects of short-term exposure to O(3) on HRV, we conducted the first meta-analysis of relevant studies. The percentage change of HRV indicator(s) is the effect estimate extracted for the quantitative analysis in this study. In our meta-analysis, per 10 ppb increase in O(3) was significantly associated with decreases in the time-domain measurements, for standard deviation of the normal-to-normal (NN) interval (SDNN) −1.11% (95%CI: −1.35%, −0.87%) and for root mean square of successive differences (RMSSD) −3.26% (95%CI: −5.42%, −1.09%); in the frequency-domain measurements, for high frequency (HF) −3.01% (95%CI: −4.66%, −1.35%) and for low frequency (LF) −2.14% (95%CI: −3.83%, −0.45%). This study showed short-term exposure to O(3) was associated with reduced HRV indicators in adults, which suggested that the cardiac autonomic nervous system might be affected after O(3) exposure, contributing to the association between O(3) exposure and CVD risk. MDPI 2022-09-06 /pmc/articles/PMC9517606/ /pubmed/36141453 http://dx.doi.org/10.3390/ijerph191811186 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zong, Zhiqiang Zhang, Mengyue Xu, Kexin Zhang, Yunquan Hu, Chengyang Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis |
title | Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis |
title_full | Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis |
title_fullStr | Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis |
title_short | Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis |
title_sort | association between short-term exposure to ozone and heart rate variability: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517606/ https://www.ncbi.nlm.nih.gov/pubmed/36141453 http://dx.doi.org/10.3390/ijerph191811186 |
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