Cargando…
Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations
Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and m...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517616/ https://www.ncbi.nlm.nih.gov/pubmed/36141480 http://dx.doi.org/10.3390/ijerph191811207 |
_version_ | 1784798987372462080 |
---|---|
author | De Bie, Felix Rafael Basurto, David Kumar, Sailesh Deprest, Jan Russo, Francesca Maria |
author_facet | De Bie, Felix Rafael Basurto, David Kumar, Sailesh Deprest, Jan Russo, Francesca Maria |
author_sort | De Bie, Felix Rafael |
collection | PubMed |
description | Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and meta-analyses, when available. Indications for using sildenafil during the second and third trimester of pregnancy include maternal pulmonary hypertension, preeclampsia, preterm labor, fetal growth restriction, oligohydramnios, fetal distress, and congenital diaphragmatic hernia. For most indications, the rationale for administering prenatal sildenafil is based on limited, equivocal data from in vitro studies and rodent disease models. Clinical studies report mild maternal side effects and suggest good fetal tolerance and safety depending on the underlying pathology. |
format | Online Article Text |
id | pubmed-9517616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95176162022-09-29 Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations De Bie, Felix Rafael Basurto, David Kumar, Sailesh Deprest, Jan Russo, Francesca Maria Int J Environ Res Public Health Review Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and meta-analyses, when available. Indications for using sildenafil during the second and third trimester of pregnancy include maternal pulmonary hypertension, preeclampsia, preterm labor, fetal growth restriction, oligohydramnios, fetal distress, and congenital diaphragmatic hernia. For most indications, the rationale for administering prenatal sildenafil is based on limited, equivocal data from in vitro studies and rodent disease models. Clinical studies report mild maternal side effects and suggest good fetal tolerance and safety depending on the underlying pathology. MDPI 2022-09-06 /pmc/articles/PMC9517616/ /pubmed/36141480 http://dx.doi.org/10.3390/ijerph191811207 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review De Bie, Felix Rafael Basurto, David Kumar, Sailesh Deprest, Jan Russo, Francesca Maria Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations |
title | Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations |
title_full | Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations |
title_fullStr | Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations |
title_full_unstemmed | Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations |
title_short | Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations |
title_sort | sildenafil during the 2nd and 3rd trimester of pregnancy: trials and tribulations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517616/ https://www.ncbi.nlm.nih.gov/pubmed/36141480 http://dx.doi.org/10.3390/ijerph191811207 |
work_keys_str_mv | AT debiefelixrafael sildenafilduringthe2ndand3rdtrimesterofpregnancytrialsandtribulations AT basurtodavid sildenafilduringthe2ndand3rdtrimesterofpregnancytrialsandtribulations AT kumarsailesh sildenafilduringthe2ndand3rdtrimesterofpregnancytrialsandtribulations AT deprestjan sildenafilduringthe2ndand3rdtrimesterofpregnancytrialsandtribulations AT russofrancescamaria sildenafilduringthe2ndand3rdtrimesterofpregnancytrialsandtribulations |