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Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations

Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and m...

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Autores principales: De Bie, Felix Rafael, Basurto, David, Kumar, Sailesh, Deprest, Jan, Russo, Francesca Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517616/
https://www.ncbi.nlm.nih.gov/pubmed/36141480
http://dx.doi.org/10.3390/ijerph191811207
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author De Bie, Felix Rafael
Basurto, David
Kumar, Sailesh
Deprest, Jan
Russo, Francesca Maria
author_facet De Bie, Felix Rafael
Basurto, David
Kumar, Sailesh
Deprest, Jan
Russo, Francesca Maria
author_sort De Bie, Felix Rafael
collection PubMed
description Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and meta-analyses, when available. Indications for using sildenafil during the second and third trimester of pregnancy include maternal pulmonary hypertension, preeclampsia, preterm labor, fetal growth restriction, oligohydramnios, fetal distress, and congenital diaphragmatic hernia. For most indications, the rationale for administering prenatal sildenafil is based on limited, equivocal data from in vitro studies and rodent disease models. Clinical studies report mild maternal side effects and suggest good fetal tolerance and safety depending on the underlying pathology.
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spelling pubmed-95176162022-09-29 Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations De Bie, Felix Rafael Basurto, David Kumar, Sailesh Deprest, Jan Russo, Francesca Maria Int J Environ Res Public Health Review Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and meta-analyses, when available. Indications for using sildenafil during the second and third trimester of pregnancy include maternal pulmonary hypertension, preeclampsia, preterm labor, fetal growth restriction, oligohydramnios, fetal distress, and congenital diaphragmatic hernia. For most indications, the rationale for administering prenatal sildenafil is based on limited, equivocal data from in vitro studies and rodent disease models. Clinical studies report mild maternal side effects and suggest good fetal tolerance and safety depending on the underlying pathology. MDPI 2022-09-06 /pmc/articles/PMC9517616/ /pubmed/36141480 http://dx.doi.org/10.3390/ijerph191811207 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
De Bie, Felix Rafael
Basurto, David
Kumar, Sailesh
Deprest, Jan
Russo, Francesca Maria
Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations
title Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations
title_full Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations
title_fullStr Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations
title_full_unstemmed Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations
title_short Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations
title_sort sildenafil during the 2nd and 3rd trimester of pregnancy: trials and tribulations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517616/
https://www.ncbi.nlm.nih.gov/pubmed/36141480
http://dx.doi.org/10.3390/ijerph191811207
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