Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland

By the end of July 2021, the majority of the Icelandic population had received vaccination against COVID-19. In mid-July a wave of SARS-CoV-2 infections, dominated by the Delta variant, spread through the population, followed by an Omicron wave in December. A booster vaccination campaign was initiat...

Descripción completa

Detalles Bibliográficos
Autores principales: Norddahl, Gudmundur L., Melsted, Pall, Gunnarsdottir, Kristbjorg, Halldorsson, Gisli H., Olafsdottir, Thorunn A., Gylfason, Arnaldur, Kristjansson, Mar, Magnusson, Olafur T., Sulem, Patrick, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Stefansson, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517986/
https://www.ncbi.nlm.nih.gov/pubmed/36171188
http://dx.doi.org/10.1038/s41467-022-33076-4
_version_ 1784799074043559936
author Norddahl, Gudmundur L.
Melsted, Pall
Gunnarsdottir, Kristbjorg
Halldorsson, Gisli H.
Olafsdottir, Thorunn A.
Gylfason, Arnaldur
Kristjansson, Mar
Magnusson, Olafur T.
Sulem, Patrick
Gudbjartsson, Daniel F.
Thorsteinsdottir, Unnur
Jonsdottir, Ingileif
Stefansson, Kari
author_facet Norddahl, Gudmundur L.
Melsted, Pall
Gunnarsdottir, Kristbjorg
Halldorsson, Gisli H.
Olafsdottir, Thorunn A.
Gylfason, Arnaldur
Kristjansson, Mar
Magnusson, Olafur T.
Sulem, Patrick
Gudbjartsson, Daniel F.
Thorsteinsdottir, Unnur
Jonsdottir, Ingileif
Stefansson, Kari
author_sort Norddahl, Gudmundur L.
collection PubMed
description By the end of July 2021, the majority of the Icelandic population had received vaccination against COVID-19. In mid-July a wave of SARS-CoV-2 infections, dominated by the Delta variant, spread through the population, followed by an Omicron wave in December. A booster vaccination campaign was initiated to curb the spread of the virus. We estimate the risk of infection for different vaccine combinations using vaccination data from 276,028 persons and 963,557 qPCR tests for 277,687 persons. We measure anti-Spike-RBD antibody levels and ACE2-Spike binding inhibitory activity in 371 persons who received one of four recommended vaccination schedules with or without an mRNA vaccine booster. Overall, we find different antibody levels and inhibitory activity in recommended vaccination schedules, reflected in the observed risk of SARS-CoV-2 infections. We observe an increased protection following mRNA boosters, against both Omicron and Delta variant infections, although BNT162b2 boosters provide greater protection against Omicron than mRNA-1273 boosters.
format Online
Article
Text
id pubmed-9517986
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-95179862022-09-29 Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland Norddahl, Gudmundur L. Melsted, Pall Gunnarsdottir, Kristbjorg Halldorsson, Gisli H. Olafsdottir, Thorunn A. Gylfason, Arnaldur Kristjansson, Mar Magnusson, Olafur T. Sulem, Patrick Gudbjartsson, Daniel F. Thorsteinsdottir, Unnur Jonsdottir, Ingileif Stefansson, Kari Nat Commun Article By the end of July 2021, the majority of the Icelandic population had received vaccination against COVID-19. In mid-July a wave of SARS-CoV-2 infections, dominated by the Delta variant, spread through the population, followed by an Omicron wave in December. A booster vaccination campaign was initiated to curb the spread of the virus. We estimate the risk of infection for different vaccine combinations using vaccination data from 276,028 persons and 963,557 qPCR tests for 277,687 persons. We measure anti-Spike-RBD antibody levels and ACE2-Spike binding inhibitory activity in 371 persons who received one of four recommended vaccination schedules with or without an mRNA vaccine booster. Overall, we find different antibody levels and inhibitory activity in recommended vaccination schedules, reflected in the observed risk of SARS-CoV-2 infections. We observe an increased protection following mRNA boosters, against both Omicron and Delta variant infections, although BNT162b2 boosters provide greater protection against Omicron than mRNA-1273 boosters. Nature Publishing Group UK 2022-09-28 /pmc/articles/PMC9517986/ /pubmed/36171188 http://dx.doi.org/10.1038/s41467-022-33076-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Norddahl, Gudmundur L.
Melsted, Pall
Gunnarsdottir, Kristbjorg
Halldorsson, Gisli H.
Olafsdottir, Thorunn A.
Gylfason, Arnaldur
Kristjansson, Mar
Magnusson, Olafur T.
Sulem, Patrick
Gudbjartsson, Daniel F.
Thorsteinsdottir, Unnur
Jonsdottir, Ingileif
Stefansson, Kari
Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland
title Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland
title_full Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland
title_fullStr Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland
title_full_unstemmed Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland
title_short Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland
title_sort effect of booster vaccination against delta and omicron sars-cov-2 variants in iceland
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517986/
https://www.ncbi.nlm.nih.gov/pubmed/36171188
http://dx.doi.org/10.1038/s41467-022-33076-4
work_keys_str_mv AT norddahlgudmundurl effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT melstedpall effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT gunnarsdottirkristbjorg effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT halldorssongislih effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT olafsdottirthorunna effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT gylfasonarnaldur effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT kristjanssonmar effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT magnussonolafurt effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT sulempatrick effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT gudbjartssondanielf effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT thorsteinsdottirunnur effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT jonsdottiringileif effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland
AT stefanssonkari effectofboostervaccinationagainstdeltaandomicronsarscov2variantsiniceland

Ejemplares similares