Cargando…

Structure of the Ebola virus polymerase complex

Filoviruses, including Ebola virus, pose an increasing threat to the public health. Although two therapeutic monoclonal antibodies have been approved to treat the Ebola virus disease(1,2), there are no approved broadly reactive drugs to control diverse filovirus infection. Filovirus has a large poly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Bin, Peng, Qi, Cheng, Jinlong, Wang, Min, Zhong, Jin, Qi, Jianxun, Gao, George F., Shi, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517992/ https://www.ncbi.nlm.nih.gov/pubmed/36171293 http://dx.doi.org/10.1038/s41586-022-05271-2

Ejemplares similares

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2
por: Peng, Qi, et al.
Publicado: (2020)

Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir
por: Peng, Qi, et al.
Publicado: (2021)

Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus
por: Tchesnokov, Egor P., et al.
Publicado: (2018)

Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein
por: Yi, Dongrong, et al.
Publicado: (2022)

Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1
por: Wang, Han, et al.
Publicado: (2016)

In vitro assembly of Ebola virus nucleocapsid-like complex expressed in E. coli
por: Peng, Ruchao, et al.
Publicado: (2016)

Characterization of the catalytic center of the Ebola virus L polymerase
por: Schmidt, Marie Luisa, et al.
Publicado: (2017)

Structure of the Respiratory Syncytial Virus Polymerase Complex
por: Gilman, Morgan S.A., et al.
Publicado: (2019)

An Upstream Open Reading Frame Modulates Ebola Virus Polymerase Translation and Virus Replication
por: Shabman, Reed S., et al.
Publicado: (2013)

Ebola virus VP35 has novel NTPase and helicase-like activities
por: Shu, Ting, et al.
Publicado: (2019)

Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases
por: Lo, Michael K., et al.
Publicado: (2020)

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
por: Tchesnokov, Egor P., et al.
Publicado: (2019)

Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes
por: Dong, Xiaofeng, et al.
Publicado: (2023)

Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replication
por: Fang, Jingru, et al.
Publicado: (2022)

Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D
por: Li, An, et al.
Publicado: (2017)

Potent neutralizing monoclonal antibodies against Ebola virus infection
por: Zhang, Qi, et al.
Publicado: (2016)

One-Step Reverse Transcription-Polymerase Chain Reaction for Ebola and Marburg Viruses
por: Park, Sun-Whan, et al.
Publicado: (2016)

Structures of Ebola Virus GP and sGP in Complex with Therapeutic Antibodies
por: Pallesen, Jesper, et al.
Publicado: (2016)

Contribution of intertwined loop to membrane association revealed by Zika virus full‐length NS1 structure
por: Xu, Xiaoying, et al.
Publicado: (2016)

Characterization of the Ebola virus nucleoprotein–RNA complex
por: Noda, Takeshi, et al.
Publicado: (2010)

Identification and characterization of short leader and trailer RNAs synthesized by the Ebola virus RNA polymerase
por: Bach, Simone, et al.
Publicado: (2021)

Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories
por: Fang, Jingru, et al.
Publicado: (2023)

Structure and assembly of the Ebola virus nucleocapsid
por: Wan, William, et al.
Publicado: (2017)

Insight into the Ebola virus nucleocapsid assembly mechanism: crystal structure of Ebola virus nucleoprotein core domain at 1.8 Å resolution
por: Dong, Shishang, et al.
Publicado: (2015)

Can Ebola virus become endemic in the human population?
por: Wong, Gary, et al.
Publicado: (2015)

Modeling the transmission dynamics of Ebola virus disease in Liberia
por: Xia, Zhi-Qiang, et al.
Publicado: (2015)

Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex
por: Wang, Qihui, et al.
Publicado: (2019)

Analysis of Ebola virus polymerase domains to find strain-specific differences and to gain insight on their pathogenicity
por: Patel, Seema, et al.
Publicado: (2016)

Structure of Machupo virus polymerase in complex with matrix protein Z
por: Ma, Jun, et al.
Publicado: (2021)

Structural and Functional Aspects of Ebola Virus Proteins
por: Jain, Sahil, et al.
Publicado: (2021)

Structure of the Inmazeb cocktail and resistance to Ebola virus escape
por: Rayaprolu, Vamseedhar, et al.
Publicado: (2023)

Age and Ebola viral load correlate with mortality and survival time in 288 Ebola virus disease patients
por: Li, Jin, et al.
Publicado: (2016)

Ebola Virus Persistence in Ocular Tissues and Fluids (EVICT) Study: Reverse Transcription-Polymerase Chain Reaction and Cataract Surgery Outcomes of Ebola Survivors in Sierra Leone()
por: Shantha, Jessica G., et al.
Publicado: (2018)

Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target
por: Li, Changyao, et al.
Publicado: (2019)

Ebola Virus Entry: A Curious and Complex Series of Events
por: Moller-Tank, Sven, et al.
Publicado: (2015)

Ebola Virus Transmission Initiated by Systemic Ebola Virus Disease Relapse
por: Mbala-Kingebeni, Placide, et al.
Publicado: (2021)

Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus
por: Zhang, Wei, et al.
Publicado: (2010)

Chemical and Structural Aspects of Ebola Virus Entry Inhibitors
por: Nyakatura, Elisabeth K., et al.
Publicado: (2014)

Development of a New Reverse Genetics System for Ebola Virus
por: Gan, Tianyu, et al.
Publicado: (2021)

Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus
por: Lai, Kang Yiu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8bupp28el73mu3odjkbnibls6g