Cargando…

Latent Tuberculosis Infection in Haematopoietic Stem Cell Transplant Recipients: A Retrospective Italian Cohort Study in Tor Vergata University Hospital, Rome

The results of tuberculosis (TB) screening and reactivation in a cohort of 323 adult patients undergoing haematopoietic stem cell transplantation (HSCT) from 2015 to 2019 at the University Hospital of Tor Vergata, Rome, Italy, were reported. A total of 260 patients, 59 (18.3%) autologous and 264 (81...

Descripción completa

Detalles Bibliográficos
Autores principales: Compagno, Mirko, Navarra, Assunta, Campogiani, Laura, Coppola, Luigi, Rossi, Benedetta, Iannetta, Marco, Malagnino, Vincenzo, Parisi, Saverio G., Mariotti, Benedetta, Cerretti, Raffaella, Arcese, William, Goletti, Delia, Andreoni, Massimo, Sarmati, Loredana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518118/
https://www.ncbi.nlm.nih.gov/pubmed/36078409
http://dx.doi.org/10.3390/ijerph191710693
_version_ 1784799105582628864
author Compagno, Mirko
Navarra, Assunta
Campogiani, Laura
Coppola, Luigi
Rossi, Benedetta
Iannetta, Marco
Malagnino, Vincenzo
Parisi, Saverio G.
Mariotti, Benedetta
Cerretti, Raffaella
Arcese, William
Goletti, Delia
Andreoni, Massimo
Sarmati, Loredana
author_facet Compagno, Mirko
Navarra, Assunta
Campogiani, Laura
Coppola, Luigi
Rossi, Benedetta
Iannetta, Marco
Malagnino, Vincenzo
Parisi, Saverio G.
Mariotti, Benedetta
Cerretti, Raffaella
Arcese, William
Goletti, Delia
Andreoni, Massimo
Sarmati, Loredana
author_sort Compagno, Mirko
collection PubMed
description The results of tuberculosis (TB) screening and reactivation in a cohort of 323 adult patients undergoing haematopoietic stem cell transplantation (HSCT) from 2015 to 2019 at the University Hospital of Tor Vergata, Rome, Italy, were reported. A total of 260 patients, 59 (18.3%) autologous and 264 (81.7%) allogeneic transplants, underwent Interferon Release (IFN)-γ (IGRA) test screening: 228 (87.7%) were negative, 11 (4.2%) indeterminate and 21 (8.1%) positive. Most of the IGRA-positive patients were of Italian origin (95.2%) and significantly older than the IGRA-negative (p < 0.001); 22 (8.5%) patients underwent a second IGRA during the first year after transplantation, and 1 tested positive for IGRA. Significantly lower monocyte (p = 0.044) and lymphocyte counts (p = 0.009) were detected in IGRA negative and IGRA indeterminate patients, respectively. All latent TB patients underwent isoniazid prophylaxis, and none of them progressed to active TB over a median follow-up period of 63.4 months. A significant decline in TB screening practices was shown from 2015 to 2019, and approximately 19% of patients were not screened. In conclusion, 8.1% of our HSCT population had LTBI, all received INH treatment, and no reactivation of TB was observed during the follow-up period. In addition, 19% escaped screening and 8% of these came from countries with a medium TB burden, therefore at higher risk of possible development of TB.
format Online
Article
Text
id pubmed-9518118
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95181182022-09-29 Latent Tuberculosis Infection in Haematopoietic Stem Cell Transplant Recipients: A Retrospective Italian Cohort Study in Tor Vergata University Hospital, Rome Compagno, Mirko Navarra, Assunta Campogiani, Laura Coppola, Luigi Rossi, Benedetta Iannetta, Marco Malagnino, Vincenzo Parisi, Saverio G. Mariotti, Benedetta Cerretti, Raffaella Arcese, William Goletti, Delia Andreoni, Massimo Sarmati, Loredana Int J Environ Res Public Health Article The results of tuberculosis (TB) screening and reactivation in a cohort of 323 adult patients undergoing haematopoietic stem cell transplantation (HSCT) from 2015 to 2019 at the University Hospital of Tor Vergata, Rome, Italy, were reported. A total of 260 patients, 59 (18.3%) autologous and 264 (81.7%) allogeneic transplants, underwent Interferon Release (IFN)-γ (IGRA) test screening: 228 (87.7%) were negative, 11 (4.2%) indeterminate and 21 (8.1%) positive. Most of the IGRA-positive patients were of Italian origin (95.2%) and significantly older than the IGRA-negative (p < 0.001); 22 (8.5%) patients underwent a second IGRA during the first year after transplantation, and 1 tested positive for IGRA. Significantly lower monocyte (p = 0.044) and lymphocyte counts (p = 0.009) were detected in IGRA negative and IGRA indeterminate patients, respectively. All latent TB patients underwent isoniazid prophylaxis, and none of them progressed to active TB over a median follow-up period of 63.4 months. A significant decline in TB screening practices was shown from 2015 to 2019, and approximately 19% of patients were not screened. In conclusion, 8.1% of our HSCT population had LTBI, all received INH treatment, and no reactivation of TB was observed during the follow-up period. In addition, 19% escaped screening and 8% of these came from countries with a medium TB burden, therefore at higher risk of possible development of TB. MDPI 2022-08-27 /pmc/articles/PMC9518118/ /pubmed/36078409 http://dx.doi.org/10.3390/ijerph191710693 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Compagno, Mirko
Navarra, Assunta
Campogiani, Laura
Coppola, Luigi
Rossi, Benedetta
Iannetta, Marco
Malagnino, Vincenzo
Parisi, Saverio G.
Mariotti, Benedetta
Cerretti, Raffaella
Arcese, William
Goletti, Delia
Andreoni, Massimo
Sarmati, Loredana
Latent Tuberculosis Infection in Haematopoietic Stem Cell Transplant Recipients: A Retrospective Italian Cohort Study in Tor Vergata University Hospital, Rome
title Latent Tuberculosis Infection in Haematopoietic Stem Cell Transplant Recipients: A Retrospective Italian Cohort Study in Tor Vergata University Hospital, Rome
title_full Latent Tuberculosis Infection in Haematopoietic Stem Cell Transplant Recipients: A Retrospective Italian Cohort Study in Tor Vergata University Hospital, Rome
title_fullStr Latent Tuberculosis Infection in Haematopoietic Stem Cell Transplant Recipients: A Retrospective Italian Cohort Study in Tor Vergata University Hospital, Rome
title_full_unstemmed Latent Tuberculosis Infection in Haematopoietic Stem Cell Transplant Recipients: A Retrospective Italian Cohort Study in Tor Vergata University Hospital, Rome
title_short Latent Tuberculosis Infection in Haematopoietic Stem Cell Transplant Recipients: A Retrospective Italian Cohort Study in Tor Vergata University Hospital, Rome
title_sort latent tuberculosis infection in haematopoietic stem cell transplant recipients: a retrospective italian cohort study in tor vergata university hospital, rome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518118/
https://www.ncbi.nlm.nih.gov/pubmed/36078409
http://dx.doi.org/10.3390/ijerph191710693
work_keys_str_mv AT compagnomirko latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT navarraassunta latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT campogianilaura latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT coppolaluigi latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT rossibenedetta latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT iannettamarco latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT malagninovincenzo latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT parisisaveriog latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT mariottibenedetta latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT cerrettiraffaella latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT arcesewilliam latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT golettidelia latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT andreonimassimo latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome
AT sarmatiloredana latenttuberculosisinfectioninhaematopoieticstemcelltransplantrecipientsaretrospectiveitaliancohortstudyintorvergatauniversityhospitalrome