Cargando…
Comprehensive Time-Course Effects of Combined Training on Hypertensive Older Adults: A Randomized Control Trial
The aim was to identify whether 16 weeks of combined training (Training) reduces blood pressure of hypertensive older adults and what the key fitness, hemodynamic, autonomic, inflammatory, oxidative, glucose and/or lipid mediators of this intervention would be. Fifty-two individuals were randomized...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518134/ https://www.ncbi.nlm.nih.gov/pubmed/36078774 http://dx.doi.org/10.3390/ijerph191711042 |
_version_ | 1784799109554634752 |
---|---|
author | Sardeli, Amanda V. Gáspari, Arthur F. dos Santos, Wellington M. de Araujo, Amanda A. de Angelis, Kátia Mariano, Lilian O. Cavaglieri, Cláudia R. Fernhall, Bo Chacon-Mikahil, Mara Patrícia T. |
author_facet | Sardeli, Amanda V. Gáspari, Arthur F. dos Santos, Wellington M. de Araujo, Amanda A. de Angelis, Kátia Mariano, Lilian O. Cavaglieri, Cláudia R. Fernhall, Bo Chacon-Mikahil, Mara Patrícia T. |
author_sort | Sardeli, Amanda V. |
collection | PubMed |
description | The aim was to identify whether 16 weeks of combined training (Training) reduces blood pressure of hypertensive older adults and what the key fitness, hemodynamic, autonomic, inflammatory, oxidative, glucose and/or lipid mediators of this intervention would be. Fifty-two individuals were randomized to either 16 weeks of Training or control group who remained physically inactive (Control). Training included walking/running at 63% of [Formula: see text] O(2)max, three times per week, and strength training, consisting of one set of fifteen repetitions (seven exercises) at moderate intensity, twice per week. Both groups underwent a comprehensive health assessment at baseline (W0) and every four weeks, for 16 weeks total. p-value ≤ 0.05 was set as significant. Training did not reduce blood pressure. It increased [Formula: see text] O(2)max after eight weeks and again after 16 weeks (~18%), differently from the Control group. At 16 weeks, Training increased strength (~8%), slightly reduced body mass (~1%), and reduced the number of individuals with metabolic syndrome (~7%). No other changes were observed (heart rate, carotid compliance, body composition, glycemic and lipid profile, inflammatory markers and oxidative profile, vasoactive substances, heart rate variability indices). Although Training increased cardiorespiratory fitness and strength, Training was able to reduce neither blood pressure nor a wide range of mediators in hypertensive older adults, suggesting other exercise interventions might be necessary to improve overall health in this population. The novelty of this study was the time-course characterization of Training effects, surprisingly demonstrating stability among a comprehensive number of health outcomes in hypertensive older adults, including blood pressure. |
format | Online Article Text |
id | pubmed-9518134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95181342022-09-29 Comprehensive Time-Course Effects of Combined Training on Hypertensive Older Adults: A Randomized Control Trial Sardeli, Amanda V. Gáspari, Arthur F. dos Santos, Wellington M. de Araujo, Amanda A. de Angelis, Kátia Mariano, Lilian O. Cavaglieri, Cláudia R. Fernhall, Bo Chacon-Mikahil, Mara Patrícia T. Int J Environ Res Public Health Article The aim was to identify whether 16 weeks of combined training (Training) reduces blood pressure of hypertensive older adults and what the key fitness, hemodynamic, autonomic, inflammatory, oxidative, glucose and/or lipid mediators of this intervention would be. Fifty-two individuals were randomized to either 16 weeks of Training or control group who remained physically inactive (Control). Training included walking/running at 63% of [Formula: see text] O(2)max, three times per week, and strength training, consisting of one set of fifteen repetitions (seven exercises) at moderate intensity, twice per week. Both groups underwent a comprehensive health assessment at baseline (W0) and every four weeks, for 16 weeks total. p-value ≤ 0.05 was set as significant. Training did not reduce blood pressure. It increased [Formula: see text] O(2)max after eight weeks and again after 16 weeks (~18%), differently from the Control group. At 16 weeks, Training increased strength (~8%), slightly reduced body mass (~1%), and reduced the number of individuals with metabolic syndrome (~7%). No other changes were observed (heart rate, carotid compliance, body composition, glycemic and lipid profile, inflammatory markers and oxidative profile, vasoactive substances, heart rate variability indices). Although Training increased cardiorespiratory fitness and strength, Training was able to reduce neither blood pressure nor a wide range of mediators in hypertensive older adults, suggesting other exercise interventions might be necessary to improve overall health in this population. The novelty of this study was the time-course characterization of Training effects, surprisingly demonstrating stability among a comprehensive number of health outcomes in hypertensive older adults, including blood pressure. MDPI 2022-09-04 /pmc/articles/PMC9518134/ /pubmed/36078774 http://dx.doi.org/10.3390/ijerph191711042 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sardeli, Amanda V. Gáspari, Arthur F. dos Santos, Wellington M. de Araujo, Amanda A. de Angelis, Kátia Mariano, Lilian O. Cavaglieri, Cláudia R. Fernhall, Bo Chacon-Mikahil, Mara Patrícia T. Comprehensive Time-Course Effects of Combined Training on Hypertensive Older Adults: A Randomized Control Trial |
title | Comprehensive Time-Course Effects of Combined Training on Hypertensive Older Adults: A Randomized Control Trial |
title_full | Comprehensive Time-Course Effects of Combined Training on Hypertensive Older Adults: A Randomized Control Trial |
title_fullStr | Comprehensive Time-Course Effects of Combined Training on Hypertensive Older Adults: A Randomized Control Trial |
title_full_unstemmed | Comprehensive Time-Course Effects of Combined Training on Hypertensive Older Adults: A Randomized Control Trial |
title_short | Comprehensive Time-Course Effects of Combined Training on Hypertensive Older Adults: A Randomized Control Trial |
title_sort | comprehensive time-course effects of combined training on hypertensive older adults: a randomized control trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518134/ https://www.ncbi.nlm.nih.gov/pubmed/36078774 http://dx.doi.org/10.3390/ijerph191711042 |
work_keys_str_mv | AT sardeliamandav comprehensivetimecourseeffectsofcombinedtrainingonhypertensiveolderadultsarandomizedcontroltrial AT gaspariarthurf comprehensivetimecourseeffectsofcombinedtrainingonhypertensiveolderadultsarandomizedcontroltrial AT dossantoswellingtonm comprehensivetimecourseeffectsofcombinedtrainingonhypertensiveolderadultsarandomizedcontroltrial AT dearaujoamandaa comprehensivetimecourseeffectsofcombinedtrainingonhypertensiveolderadultsarandomizedcontroltrial AT deangeliskatia comprehensivetimecourseeffectsofcombinedtrainingonhypertensiveolderadultsarandomizedcontroltrial AT marianoliliano comprehensivetimecourseeffectsofcombinedtrainingonhypertensiveolderadultsarandomizedcontroltrial AT cavagliericlaudiar comprehensivetimecourseeffectsofcombinedtrainingonhypertensiveolderadultsarandomizedcontroltrial AT fernhallbo comprehensivetimecourseeffectsofcombinedtrainingonhypertensiveolderadultsarandomizedcontroltrial AT chaconmikahilmarapatriciat comprehensivetimecourseeffectsofcombinedtrainingonhypertensiveolderadultsarandomizedcontroltrial |