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Design and synthesis of new indole drug candidates to treat Alzheimer’s disease and targeting neuro-inflammation using a multi-target-directed ligand (MTDL) strategy

A novel series of indole-based compounds was designed, synthesised, and evaluated as anti-Alzheimer’s and anti-neuroinflammatory agents. The designed compounds were in vitro evaluated for their AChE and BuChE inhibitory activities. The obtained results revealed that compound 3c had higher selectivit...

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Detalles Bibliográficos
Autores principales:	Lamie, Phoebe F., Abdel-Fattah, Maha M., Philoppes, John N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518246/ https://www.ncbi.nlm.nih.gov/pubmed/36146947 http://dx.doi.org/10.1080/14756366.2022.2126464

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