Cargando…

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII

In this work, different series of benzothiazole-based sulphonamides 8a-c, 10, 12, 16a-b and carboxylic acids 14a-c were developed as novel SLC-0111 analogues with the goal of generating potent carbonic anhydrase (CA) inhibitors. The adopted strategy involved replacing the 4-fluorophenyl tail in SLC-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Warhi, Tarfah, Elbadawi, Mostafa M., Bonardi, Alessandro, Nocentini, Alessio, Al-Karmalawy, Ahmed A., Aljaeed, Nada, Alotaibi, Ohoud J., Abdel-Aziz, Hatem A., Supuran, Claudiu T., Eldehna, Wagdy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518259/ https://www.ncbi.nlm.nih.gov/pubmed/36146927 http://dx.doi.org/10.1080/14756366.2022.2124409

Ejemplares similares

Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms
por: Eldehna, Wagdy M., et al.
Publicado: (2022)

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation
por: Abdelrahman, Mohamed A., et al.
Publicado: (2019)

Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors
por: Elsayed, Zainab M., et al.
Publicado: (2023)

Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII
por: El-Damasy, Ashraf K., et al.
Publicado: (2023)

Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity
por: Tawfik, Haytham O., et al.
Publicado: (2022)

Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors
por: Onyılmaz, Mehmet, et al.
Publicado: (2022)

Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion
por: Sarnella, Annachiara, et al.
Publicado: (2022)

Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment
por: Abo-Ashour, Mahmoud F., et al.
Publicado: (2022)

The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy
por: Andreucci, Elena, et al.
Publicado: (2018)

Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII
por: Giovannuzzi, Simone, et al.
Publicado: (2022)

Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis
por: Bonardi, Alessandro, et al.
Publicado: (2022)

3H-1,2-Benzoxaphosphepine 2-oxides as selective inhibitors of carbonic anhydrase IX and XII
por: Pustenko, Aleksandrs, et al.
Publicado: (2022)

Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors
por: Peerzada, Mudasir Nabi, et al.
Publicado: (2023)

Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors
por: Astrain-Redin, Nora, et al.
Publicado: (2023)

Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights
por: Abdelrahman, Mohamed A., et al.
Publicado: (2019)

A class of carbonic anhydrase IX/XII – selective carboxylate inhibitors
por: Alhameed, Rakia Abd, et al.
Publicado: (2020)

Investigation on Hydrazonobenzenesulfonamides as Human Carbonic Anhydrase I, II, IX and XII Inhibitors
por: Moi, Davide, et al.
Publicado: (2022)

Aryl derivatives of 3H-1,2-benzoxaphosphepine 2-oxides as inhibitors of cancer-related carbonic anhydrase isoforms IX and XII
por: Balašova, Anastasija, et al.
Publicado: (2023)

Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors
por: Shaldam, Moataz, et al.
Publicado: (2021)

7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors
por: Pustenko, Aleksandrs, et al.
Publicado: (2020)

Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines
por: Mussi, Silvia, et al.
Publicado: (2021)

Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII
por: Cau, Ylenia, et al.
Publicado: (2017)

The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cells
por: Peppicelli, Silvia, et al.
Publicado: (2020)

Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
por: Meleddu, Rita, et al.
Publicado: (2021)

The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII
por: Bonardi, Alessandro, et al.
Publicado: (2022)

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors
por: McDonald, Paul C., et al.
Publicado: (2020)

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights
por: Sabt, Ahmed, et al.
Publicado: (2020)

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII
por: Buran, Kerem, et al.
Publicado: (2019)

Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase
por: Krasavin, Mikhail, et al.
Publicado: (2020)

Derivatives of 4-methyl-1,2,3-benzoxathiazine 2,2-dioxide as selective inhibitors of human carbonic anhydrases IX and XII over the cytosolic isoforms I and II
por: Ivanova, Jekaterīna, et al.
Publicado: (2023)

SLC-0111, an inhibitor of carbonic anhydrase IX, attenuates hepatoblastoma cell viability and migration
por: Eloranta, Katja, et al.
Publicado: (2023)

Identification of Novel Cyanopyridones and Pyrido[2,3-d]pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII
por: Gumus, Arzu, et al.
Publicado: (2022)

Organoruthenium(II) complexes of acetazolamide potently inhibit human carbonic anhydrase isoforms I, II, IX and XII
por: Seršen, Sara, et al.
Publicado: (2019)

Inhibitory activity against carbonic anhydrase IX and XII as a candidate selection criterion in the development of new anticancer agents
por: Krasavin, Mikhail, et al.
Publicado: (2020)

S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors
por: El-Azab, Adel S., et al.
Publicado: (2020)

First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors
por: Testa, Chiara, et al.
Publicado: (2022)

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2020)

Pyrrolyl and Indolyl α-γ-Diketo Acid Derivatives Acting as Selective Inhibitors of Human Carbonic Anhydrases IX and XII
por: Ialongo, Davide, et al.
Publicado: (2023)

Carbonic Anhydrases II, IX, and XII in Reflux Esophagitis
por: Nortunen, Minna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i49lilr3r44dtenuat6vass3vm