Cargando…
Cerebrospinal fluid findings of infant tuberculous meningitis: a scoping review
BACKGROUND: Cerebrospinal fluid (CSF) examinations play an important role in the diagnosis of tuberculous meningitis (TBM). However, their yield in the diagnosis of infant TBM remains unclear. This scoping review aims to detail the role of CSF examination for the diagnosis of infant TBM. METHODS: A...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518261/ https://www.ncbi.nlm.nih.gov/pubmed/36120927 http://dx.doi.org/10.1080/07853890.2022.2123560 |
_version_ | 1784799139800809472 |
---|---|
author | Hou, Jie Liu, Xin-Jie He, Yu Zhang, Yan-An Wang, Mao-Shui |
author_facet | Hou, Jie Liu, Xin-Jie He, Yu Zhang, Yan-An Wang, Mao-Shui |
author_sort | Hou, Jie |
collection | PubMed |
description | BACKGROUND: Cerebrospinal fluid (CSF) examinations play an important role in the diagnosis of tuberculous meningitis (TBM). However, their yield in the diagnosis of infant TBM remains unclear. This scoping review aims to detail the role of CSF examination for the diagnosis of infant TBM. METHODS: A comprehensive literature search of PubMed, EBSCO, Embase, Scopus, Web of Science, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials was performed to identify articles published prior to October 14th, 2021. Articles describing the results of CSF exanimations among infant TBM were eligible for inclusion. Data extracted from each study included age, sex, CSF microbiological evidence (such as AFB smear, TB PCR, and TB culture), and routine CSF examinations (such as appearance, red blood cell count, white blood cell count, protein, and glucose). RESULTS: A total of 98 cases were included in the final analysis. The yield of microbiological methods was listed as follows: CSF AFB smear, 20.5% (9/44); CSF TB culture 47.5% (29/61); CSF TB PCR, 65.0% (26/40); the combination of them, 57.3% (47/82). According to Marais criteria, the positivities of CSF examinations were calculated as follows: WBC count (ref, 50–500/μL), 65.5% (55/84); lymphocyte predominance (ref, >0.5), 75.4% (49/65); total protein (ref, >100 mg/dL), 67.8% (59/87); glucose (ref, <2.2 mmol/L, or CSF/serum ratio < 0.5), 68.2% (58/85). CONCLUSIONS: Our data demonstrated that routine microbiological tools for infant TBM diagnosis have a sensitivity ranging from 20.5% to 65.0%, and most CSF features are non-specific and insufficient to predict a diagnosis of infant TBM. Therefore, further effort is required to develop new tools for infant TBM diagnosis. KEY MESSAGES: Routine microbiological tools (such as acid-fast bacilli smear, PCR, and culture) have an unsatisfactory sensitivity for infant TBM diagnosis, and most CSF features are non-specific and insufficient to predict a diagnosis of infant TBM. Therefore, further effort is required to develop new tools for infant TBM diagnosis. |
format | Online Article Text |
id | pubmed-9518261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-95182612022-09-29 Cerebrospinal fluid findings of infant tuberculous meningitis: a scoping review Hou, Jie Liu, Xin-Jie He, Yu Zhang, Yan-An Wang, Mao-Shui Ann Med Infectious Diseases BACKGROUND: Cerebrospinal fluid (CSF) examinations play an important role in the diagnosis of tuberculous meningitis (TBM). However, their yield in the diagnosis of infant TBM remains unclear. This scoping review aims to detail the role of CSF examination for the diagnosis of infant TBM. METHODS: A comprehensive literature search of PubMed, EBSCO, Embase, Scopus, Web of Science, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials was performed to identify articles published prior to October 14th, 2021. Articles describing the results of CSF exanimations among infant TBM were eligible for inclusion. Data extracted from each study included age, sex, CSF microbiological evidence (such as AFB smear, TB PCR, and TB culture), and routine CSF examinations (such as appearance, red blood cell count, white blood cell count, protein, and glucose). RESULTS: A total of 98 cases were included in the final analysis. The yield of microbiological methods was listed as follows: CSF AFB smear, 20.5% (9/44); CSF TB culture 47.5% (29/61); CSF TB PCR, 65.0% (26/40); the combination of them, 57.3% (47/82). According to Marais criteria, the positivities of CSF examinations were calculated as follows: WBC count (ref, 50–500/μL), 65.5% (55/84); lymphocyte predominance (ref, >0.5), 75.4% (49/65); total protein (ref, >100 mg/dL), 67.8% (59/87); glucose (ref, <2.2 mmol/L, or CSF/serum ratio < 0.5), 68.2% (58/85). CONCLUSIONS: Our data demonstrated that routine microbiological tools for infant TBM diagnosis have a sensitivity ranging from 20.5% to 65.0%, and most CSF features are non-specific and insufficient to predict a diagnosis of infant TBM. Therefore, further effort is required to develop new tools for infant TBM diagnosis. KEY MESSAGES: Routine microbiological tools (such as acid-fast bacilli smear, PCR, and culture) have an unsatisfactory sensitivity for infant TBM diagnosis, and most CSF features are non-specific and insufficient to predict a diagnosis of infant TBM. Therefore, further effort is required to develop new tools for infant TBM diagnosis. Taylor & Francis 2022-09-18 /pmc/articles/PMC9518261/ /pubmed/36120927 http://dx.doi.org/10.1080/07853890.2022.2123560 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Infectious Diseases Hou, Jie Liu, Xin-Jie He, Yu Zhang, Yan-An Wang, Mao-Shui Cerebrospinal fluid findings of infant tuberculous meningitis: a scoping review |
title | Cerebrospinal fluid findings of infant tuberculous meningitis: a scoping review |
title_full | Cerebrospinal fluid findings of infant tuberculous meningitis: a scoping review |
title_fullStr | Cerebrospinal fluid findings of infant tuberculous meningitis: a scoping review |
title_full_unstemmed | Cerebrospinal fluid findings of infant tuberculous meningitis: a scoping review |
title_short | Cerebrospinal fluid findings of infant tuberculous meningitis: a scoping review |
title_sort | cerebrospinal fluid findings of infant tuberculous meningitis: a scoping review |
topic | Infectious Diseases |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518261/ https://www.ncbi.nlm.nih.gov/pubmed/36120927 http://dx.doi.org/10.1080/07853890.2022.2123560 |
work_keys_str_mv | AT houjie cerebrospinalfluidfindingsofinfanttuberculousmeningitisascopingreview AT liuxinjie cerebrospinalfluidfindingsofinfanttuberculousmeningitisascopingreview AT heyu cerebrospinalfluidfindingsofinfanttuberculousmeningitisascopingreview AT zhangyanan cerebrospinalfluidfindingsofinfanttuberculousmeningitisascopingreview AT wangmaoshui cerebrospinalfluidfindingsofinfanttuberculousmeningitisascopingreview |