Design, synthesis, biological evaluation and molecular docking study of 2,4-diarylimidazoles and 2,4-bis(benzyloxy)-5-arylpyrimidines as novel HSP90 N-terminal inhibitors

The molecular chaperone HSP90 plays an essential role in cancer occurrence and development. Therefore, it is an important target for the development of anticancer drugs. 1,3-Dibenzyl-2-aryl imidazolidine (8) is a previously reported inhibitor of HSP90; however, its anticancer activity is poor. In th...

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Detalles Bibliográficos
Autores principales: Yang, Man, Li, Chenyao, Li, Yajing, Cheng, Chen, Shi, Meiyun, Yin, Lei, Xue, Hongyu, Liu, Yajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518286/
https://www.ncbi.nlm.nih.gov/pubmed/36120957
http://dx.doi.org/10.1080/14756366.2022.2124407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518286/
https://www.ncbi.nlm.nih.gov/pubmed/36120957
http://dx.doi.org/10.1080/14756366.2022.2124407

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