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Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway

CONTEXT: Acute promyelocytic leukaemia (APL) is a malignant hematological tumour characterized by the presence of promyelocytic leukaemia–retinoic acid receptor A (PML-RARA) fusion protein. Cinobufagin (CBG) is one of the main effective components of toad venom with antitumor properties. However, on...

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Detalles Bibliográficos
Autores principales:	Bian, Yaoyao, Xue, Mei, Guo, Xinlong, Jiang, Wenjuan, Zhao, Ye, Zhang, Zhaofeng, Wang, Xian, Hu, Yongkang, Zhang, Qi, Dun, Wenliang, Zhang, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518602/ https://www.ncbi.nlm.nih.gov/pubmed/36121296 http://dx.doi.org/10.1080/13880209.2022.2118792

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