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Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study

INTRODUCTION: The unprecedented coronavirus disease 2019 (COVID-19) pandemic has affected kidney transplant (KT) recipients, with worldwide fatality rates around 25%. Considering the well-known Brazilian socio-demographic disparities, this report describes for the first time the main outcomes of COV...

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Autores principales: Cristelli, Marina Pontello, de Sandes-Freitas, Tainá Veras, Viana, Laila Almeida, Requião-Moura, Lúcio R., de Andrade, Luis Gustavo Modelli, Tedesco-Silva, Helio, Medina-Pestana, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Nefrologia 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518611/
https://www.ncbi.nlm.nih.gov/pubmed/34328168
http://dx.doi.org/10.1590/2175-8239-JBN-2021-0063
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author Cristelli, Marina Pontello
de Sandes-Freitas, Tainá Veras
Viana, Laila Almeida
Requião-Moura, Lúcio R.
de Andrade, Luis Gustavo Modelli
Tedesco-Silva, Helio
Medina-Pestana, José
author_facet Cristelli, Marina Pontello
de Sandes-Freitas, Tainá Veras
Viana, Laila Almeida
Requião-Moura, Lúcio R.
de Andrade, Luis Gustavo Modelli
Tedesco-Silva, Helio
Medina-Pestana, José
author_sort Cristelli, Marina Pontello
collection PubMed
description INTRODUCTION: The unprecedented coronavirus disease 2019 (COVID-19) pandemic has affected kidney transplant (KT) recipients, with worldwide fatality rates around 25%. Considering the well-known Brazilian socio-demographic disparities, this report describes for the first time the main outcomes of COVID-19 in KT recipients according to Brazilian geographic regions. METHODS: This multicenter national retrospective analysis included data from KT recipients with confirmed COVID-19 between March and November 2020. RESULTS: Thirty-five of the 81 centers (57% of KT activity in Brazil) reported 1,680 patients with COVID-19. The Northeast was the first to reach the peak in the number of infections. The Southeast, due to its population density, contributed with the largest number of patients. Patients had a median age of 52 years, 76% had hypertension and 34% diabetes, 75% were recipients of a deceased donor, and the time interval between diagnosis and transplantation was 5.9 years. In 53% of patients, immunosuppression was adjusted, and clinical support varied according to geographic region. Hospitalization was required for 65% of the patients, 35% of them needed intensive care, 25% mechanical ventilation, and 23% renal replacement therapy. The 90-day overall fatality was 21%, being 23% in the Southeast, 16% in the Northeast, and 19% in the Central-west and South regions. CONCLUSION: The migratory pattern of the pandemic among KT recipients followed that of the general population and the outcomes were influenced by regional features. COVID-19 in KT recipients was associated with high utilization of health-care resources and higher fatality rates than those reported in the general population.
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spelling pubmed-95186112022-10-13 Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study Cristelli, Marina Pontello de Sandes-Freitas, Tainá Veras Viana, Laila Almeida Requião-Moura, Lúcio R. de Andrade, Luis Gustavo Modelli Tedesco-Silva, Helio Medina-Pestana, José J Bras Nefrol Brief Communication INTRODUCTION: The unprecedented coronavirus disease 2019 (COVID-19) pandemic has affected kidney transplant (KT) recipients, with worldwide fatality rates around 25%. Considering the well-known Brazilian socio-demographic disparities, this report describes for the first time the main outcomes of COVID-19 in KT recipients according to Brazilian geographic regions. METHODS: This multicenter national retrospective analysis included data from KT recipients with confirmed COVID-19 between March and November 2020. RESULTS: Thirty-five of the 81 centers (57% of KT activity in Brazil) reported 1,680 patients with COVID-19. The Northeast was the first to reach the peak in the number of infections. The Southeast, due to its population density, contributed with the largest number of patients. Patients had a median age of 52 years, 76% had hypertension and 34% diabetes, 75% were recipients of a deceased donor, and the time interval between diagnosis and transplantation was 5.9 years. In 53% of patients, immunosuppression was adjusted, and clinical support varied according to geographic region. Hospitalization was required for 65% of the patients, 35% of them needed intensive care, 25% mechanical ventilation, and 23% renal replacement therapy. The 90-day overall fatality was 21%, being 23% in the Southeast, 16% in the Northeast, and 19% in the Central-west and South regions. CONCLUSION: The migratory pattern of the pandemic among KT recipients followed that of the general population and the outcomes were influenced by regional features. COVID-19 in KT recipients was associated with high utilization of health-care resources and higher fatality rates than those reported in the general population. Sociedade Brasileira de Nefrologia 2021-07-28 2022 /pmc/articles/PMC9518611/ /pubmed/34328168 http://dx.doi.org/10.1590/2175-8239-JBN-2021-0063 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Cristelli, Marina Pontello
de Sandes-Freitas, Tainá Veras
Viana, Laila Almeida
Requião-Moura, Lúcio R.
de Andrade, Luis Gustavo Modelli
Tedesco-Silva, Helio
Medina-Pestana, José
Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study
title Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study
title_full Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study
title_fullStr Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study
title_full_unstemmed Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study
title_short Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study
title_sort migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the brazilian multicenter cohort study
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518611/
https://www.ncbi.nlm.nih.gov/pubmed/34328168
http://dx.doi.org/10.1590/2175-8239-JBN-2021-0063
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