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Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults

Introduction: Few studies are available on the prevalence and sleep-related factors of dementia with Lewy bodies (DLB) in Chinese older adults, aiming to explore the associations between sleep characteristics and DLB. Methods: A cross-sectional study with 7,528 individuals aged ≥65 years in 106 comm...

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Autores principales: Gan, Jinghuan, Liu, Shuai, Wang, Fei, Shi, Zhihong, Lü, Yang, Niu, Jianping, Meng, Xinling, Cai, Pan, Wang, Xiao-Dan, Chen, Zhichao, Gang, Baozhi, Ji, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518672/
https://www.ncbi.nlm.nih.gov/pubmed/36188174
http://dx.doi.org/10.3389/fnhum.2022.976753
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author Gan, Jinghuan
Liu, Shuai
Wang, Fei
Shi, Zhihong
Lü, Yang
Niu, Jianping
Meng, Xinling
Cai, Pan
Wang, Xiao-Dan
Chen, Zhichao
Gang, Baozhi
Ji, Yong
author_facet Gan, Jinghuan
Liu, Shuai
Wang, Fei
Shi, Zhihong
Lü, Yang
Niu, Jianping
Meng, Xinling
Cai, Pan
Wang, Xiao-Dan
Chen, Zhichao
Gang, Baozhi
Ji, Yong
author_sort Gan, Jinghuan
collection PubMed
description Introduction: Few studies are available on the prevalence and sleep-related factors of dementia with Lewy bodies (DLB) in Chinese older adults, aiming to explore the associations between sleep characteristics and DLB. Methods: A cross-sectional study with 7,528 individuals aged ≥65 years in 106 communities in Northern China was conducted from April 2019 to January 2020. Questionaries (including demographic characteristics, comorbidities, lifestyles, and sleep characteristics) were administered, and neuropsychological assessments and physical examination were conducted in phase I; screening for probable DLB was done in phase II. Logistic regressions were used to assess associations. Results: A total of 919 (12.2%, 919/7,528) participants had dementia, and 101 (1.3%, 101/7,528) participants were diagnosed with DLB. The prevalence of dementia and DLB were slightly higher or equal in women, increased with age, and roughly decreased with nighttime sleep duration. Of the 101 participants, all of them (100.0%) had cognitive impairment, 46 (44.54%) displayed fluctuating cognition, 72 (71.29%) of them showed visual hallucination, 22 (21.78%) individuals reported RBD, and 27.71% showed Parkinsonism. Sleeping for <5 h (adjusted OR = 1.795, 95%CI: 1.055–3.054, p < 0.05) or having hypersomnolence (adjusted OR = 31.213, 95% CI: 17.618–55.301, p < 0.001) were significantly associated with the occurrence of DLB. Sleep duration of <5 h or >8 h had combined diagnostic value for DLB (AUC = 0.783, 95%CI: 0.734–0.831, p < 0.001). Conclusions: The current prevalence of DLB is 1.3% in Northern China. Short or long nighttime sleep duration is independently associated with the occurrence of dementia and DLB.
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spelling pubmed-95186722022-09-29 Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults Gan, Jinghuan Liu, Shuai Wang, Fei Shi, Zhihong Lü, Yang Niu, Jianping Meng, Xinling Cai, Pan Wang, Xiao-Dan Chen, Zhichao Gang, Baozhi Ji, Yong Front Hum Neurosci Human Neuroscience Introduction: Few studies are available on the prevalence and sleep-related factors of dementia with Lewy bodies (DLB) in Chinese older adults, aiming to explore the associations between sleep characteristics and DLB. Methods: A cross-sectional study with 7,528 individuals aged ≥65 years in 106 communities in Northern China was conducted from April 2019 to January 2020. Questionaries (including demographic characteristics, comorbidities, lifestyles, and sleep characteristics) were administered, and neuropsychological assessments and physical examination were conducted in phase I; screening for probable DLB was done in phase II. Logistic regressions were used to assess associations. Results: A total of 919 (12.2%, 919/7,528) participants had dementia, and 101 (1.3%, 101/7,528) participants were diagnosed with DLB. The prevalence of dementia and DLB were slightly higher or equal in women, increased with age, and roughly decreased with nighttime sleep duration. Of the 101 participants, all of them (100.0%) had cognitive impairment, 46 (44.54%) displayed fluctuating cognition, 72 (71.29%) of them showed visual hallucination, 22 (21.78%) individuals reported RBD, and 27.71% showed Parkinsonism. Sleeping for <5 h (adjusted OR = 1.795, 95%CI: 1.055–3.054, p < 0.05) or having hypersomnolence (adjusted OR = 31.213, 95% CI: 17.618–55.301, p < 0.001) were significantly associated with the occurrence of DLB. Sleep duration of <5 h or >8 h had combined diagnostic value for DLB (AUC = 0.783, 95%CI: 0.734–0.831, p < 0.001). Conclusions: The current prevalence of DLB is 1.3% in Northern China. Short or long nighttime sleep duration is independently associated with the occurrence of dementia and DLB. Frontiers Media S.A. 2022-09-14 /pmc/articles/PMC9518672/ /pubmed/36188174 http://dx.doi.org/10.3389/fnhum.2022.976753 Text en Copyright © 2022 Gan, Liu, Wang, Shi, Lü, Niu, Meng, Cai, Wang, Chen, Gang and Ji. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Gan, Jinghuan
Liu, Shuai
Wang, Fei
Shi, Zhihong
Lü, Yang
Niu, Jianping
Meng, Xinling
Cai, Pan
Wang, Xiao-Dan
Chen, Zhichao
Gang, Baozhi
Ji, Yong
Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults
title Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults
title_full Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults
title_fullStr Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults
title_full_unstemmed Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults
title_short Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults
title_sort association between prevalence rate of dementia with lewy bodies and sleep characteristics in chinese old adults
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518672/
https://www.ncbi.nlm.nih.gov/pubmed/36188174
http://dx.doi.org/10.3389/fnhum.2022.976753
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