Cargando…
Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults
Introduction: Few studies are available on the prevalence and sleep-related factors of dementia with Lewy bodies (DLB) in Chinese older adults, aiming to explore the associations between sleep characteristics and DLB. Methods: A cross-sectional study with 7,528 individuals aged ≥65 years in 106 comm...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518672/ https://www.ncbi.nlm.nih.gov/pubmed/36188174 http://dx.doi.org/10.3389/fnhum.2022.976753 |
_version_ | 1784799240328839168 |
---|---|
author | Gan, Jinghuan Liu, Shuai Wang, Fei Shi, Zhihong Lü, Yang Niu, Jianping Meng, Xinling Cai, Pan Wang, Xiao-Dan Chen, Zhichao Gang, Baozhi Ji, Yong |
author_facet | Gan, Jinghuan Liu, Shuai Wang, Fei Shi, Zhihong Lü, Yang Niu, Jianping Meng, Xinling Cai, Pan Wang, Xiao-Dan Chen, Zhichao Gang, Baozhi Ji, Yong |
author_sort | Gan, Jinghuan |
collection | PubMed |
description | Introduction: Few studies are available on the prevalence and sleep-related factors of dementia with Lewy bodies (DLB) in Chinese older adults, aiming to explore the associations between sleep characteristics and DLB. Methods: A cross-sectional study with 7,528 individuals aged ≥65 years in 106 communities in Northern China was conducted from April 2019 to January 2020. Questionaries (including demographic characteristics, comorbidities, lifestyles, and sleep characteristics) were administered, and neuropsychological assessments and physical examination were conducted in phase I; screening for probable DLB was done in phase II. Logistic regressions were used to assess associations. Results: A total of 919 (12.2%, 919/7,528) participants had dementia, and 101 (1.3%, 101/7,528) participants were diagnosed with DLB. The prevalence of dementia and DLB were slightly higher or equal in women, increased with age, and roughly decreased with nighttime sleep duration. Of the 101 participants, all of them (100.0%) had cognitive impairment, 46 (44.54%) displayed fluctuating cognition, 72 (71.29%) of them showed visual hallucination, 22 (21.78%) individuals reported RBD, and 27.71% showed Parkinsonism. Sleeping for <5 h (adjusted OR = 1.795, 95%CI: 1.055–3.054, p < 0.05) or having hypersomnolence (adjusted OR = 31.213, 95% CI: 17.618–55.301, p < 0.001) were significantly associated with the occurrence of DLB. Sleep duration of <5 h or >8 h had combined diagnostic value for DLB (AUC = 0.783, 95%CI: 0.734–0.831, p < 0.001). Conclusions: The current prevalence of DLB is 1.3% in Northern China. Short or long nighttime sleep duration is independently associated with the occurrence of dementia and DLB. |
format | Online Article Text |
id | pubmed-9518672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95186722022-09-29 Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults Gan, Jinghuan Liu, Shuai Wang, Fei Shi, Zhihong Lü, Yang Niu, Jianping Meng, Xinling Cai, Pan Wang, Xiao-Dan Chen, Zhichao Gang, Baozhi Ji, Yong Front Hum Neurosci Human Neuroscience Introduction: Few studies are available on the prevalence and sleep-related factors of dementia with Lewy bodies (DLB) in Chinese older adults, aiming to explore the associations between sleep characteristics and DLB. Methods: A cross-sectional study with 7,528 individuals aged ≥65 years in 106 communities in Northern China was conducted from April 2019 to January 2020. Questionaries (including demographic characteristics, comorbidities, lifestyles, and sleep characteristics) were administered, and neuropsychological assessments and physical examination were conducted in phase I; screening for probable DLB was done in phase II. Logistic regressions were used to assess associations. Results: A total of 919 (12.2%, 919/7,528) participants had dementia, and 101 (1.3%, 101/7,528) participants were diagnosed with DLB. The prevalence of dementia and DLB were slightly higher or equal in women, increased with age, and roughly decreased with nighttime sleep duration. Of the 101 participants, all of them (100.0%) had cognitive impairment, 46 (44.54%) displayed fluctuating cognition, 72 (71.29%) of them showed visual hallucination, 22 (21.78%) individuals reported RBD, and 27.71% showed Parkinsonism. Sleeping for <5 h (adjusted OR = 1.795, 95%CI: 1.055–3.054, p < 0.05) or having hypersomnolence (adjusted OR = 31.213, 95% CI: 17.618–55.301, p < 0.001) were significantly associated with the occurrence of DLB. Sleep duration of <5 h or >8 h had combined diagnostic value for DLB (AUC = 0.783, 95%CI: 0.734–0.831, p < 0.001). Conclusions: The current prevalence of DLB is 1.3% in Northern China. Short or long nighttime sleep duration is independently associated with the occurrence of dementia and DLB. Frontiers Media S.A. 2022-09-14 /pmc/articles/PMC9518672/ /pubmed/36188174 http://dx.doi.org/10.3389/fnhum.2022.976753 Text en Copyright © 2022 Gan, Liu, Wang, Shi, Lü, Niu, Meng, Cai, Wang, Chen, Gang and Ji. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Human Neuroscience Gan, Jinghuan Liu, Shuai Wang, Fei Shi, Zhihong Lü, Yang Niu, Jianping Meng, Xinling Cai, Pan Wang, Xiao-Dan Chen, Zhichao Gang, Baozhi Ji, Yong Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults |
title | Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults |
title_full | Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults |
title_fullStr | Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults |
title_full_unstemmed | Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults |
title_short | Association between prevalence rate of dementia with Lewy bodies and sleep characteristics in Chinese old adults |
title_sort | association between prevalence rate of dementia with lewy bodies and sleep characteristics in chinese old adults |
topic | Human Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518672/ https://www.ncbi.nlm.nih.gov/pubmed/36188174 http://dx.doi.org/10.3389/fnhum.2022.976753 |
work_keys_str_mv | AT ganjinghuan associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT liushuai associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT wangfei associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT shizhihong associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT luyang associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT niujianping associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT mengxinling associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT caipan associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT wangxiaodan associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT chenzhichao associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT gangbaozhi associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults AT jiyong associationbetweenprevalencerateofdementiawithlewybodiesandsleepcharacteristicsinchineseoldadults |