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Shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer

BACKGROUND: The purpose of this study was to assess the impact of coincidental radiotherapy on the volume of the non-malignant prostate gland in rectal cancer patients treated with neo-adjuvant radiotherapy. MATERIALS AND METHODS: In this retrospective analysis, thirty male patients with rectal canc...

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Autores principales: Kovarik, Josef, Kelly, Charles, West, Nick, Drinnan, Michael, Dobrowsky, Werner, Iqbal, Muhammad Shahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Via Medica 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518781/
https://www.ncbi.nlm.nih.gov/pubmed/36186705
http://dx.doi.org/10.5603/RPOR.a2022.0026
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author Kovarik, Josef
Kelly, Charles
West, Nick
Drinnan, Michael
Dobrowsky, Werner
Iqbal, Muhammad Shahid
author_facet Kovarik, Josef
Kelly, Charles
West, Nick
Drinnan, Michael
Dobrowsky, Werner
Iqbal, Muhammad Shahid
author_sort Kovarik, Josef
collection PubMed
description BACKGROUND: The purpose of this study was to assess the impact of coincidental radiotherapy on the volume of the non-malignant prostate gland in rectal cancer patients treated with neo-adjuvant radiotherapy. MATERIALS AND METHODS: In this retrospective analysis, thirty male patients with rectal cancer who had neoadjuvant radiotherapy met the inclusion criteria. These patients had pre-treatment magnetic resonance imaging (MRI) and at least one post-treatment MRI of the pelvis and the whole of their prostate volume received the full prescribed radiotherapy dose; 45 Gy in 25 fractions (n = 22), 45 Gy in 20 fractions (n = 4) and 25 Gy in 5 fractions (n = 4). RESULTS: The median age of this patient cohort was 66 years (range: 30–87). With a median interval between pre-treatment MRI and first MRI post-treatment of 2 months (range: 1–11), the mean prostate volume reduced from 36.1 cm(3) [standard deviation (SD) 14.2] pre-radiotherapy to 31.3 cm(3) (SD 13.0) post radiotherapy and this difference was significant (p = 0.0004). CONCLUSION: Radiotherapy may cause shrinkage in volume of normal (non-malignant) prostate. Further research is required in this field, since these results may be of some comfort to men contemplating the consequences of radiotherapy on their quality of life. The authors suggest recording flow-rate and international prostate symptom score (IPSS) during rectal radiotherapy as a next step.
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spelling pubmed-95187812022-09-29 Shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer Kovarik, Josef Kelly, Charles West, Nick Drinnan, Michael Dobrowsky, Werner Iqbal, Muhammad Shahid Rep Pract Oncol Radiother Letter to the Editor BACKGROUND: The purpose of this study was to assess the impact of coincidental radiotherapy on the volume of the non-malignant prostate gland in rectal cancer patients treated with neo-adjuvant radiotherapy. MATERIALS AND METHODS: In this retrospective analysis, thirty male patients with rectal cancer who had neoadjuvant radiotherapy met the inclusion criteria. These patients had pre-treatment magnetic resonance imaging (MRI) and at least one post-treatment MRI of the pelvis and the whole of their prostate volume received the full prescribed radiotherapy dose; 45 Gy in 25 fractions (n = 22), 45 Gy in 20 fractions (n = 4) and 25 Gy in 5 fractions (n = 4). RESULTS: The median age of this patient cohort was 66 years (range: 30–87). With a median interval between pre-treatment MRI and first MRI post-treatment of 2 months (range: 1–11), the mean prostate volume reduced from 36.1 cm(3) [standard deviation (SD) 14.2] pre-radiotherapy to 31.3 cm(3) (SD 13.0) post radiotherapy and this difference was significant (p = 0.0004). CONCLUSION: Radiotherapy may cause shrinkage in volume of normal (non-malignant) prostate. Further research is required in this field, since these results may be of some comfort to men contemplating the consequences of radiotherapy on their quality of life. The authors suggest recording flow-rate and international prostate symptom score (IPSS) during rectal radiotherapy as a next step. Via Medica 2022-07-29 /pmc/articles/PMC9518781/ /pubmed/36186705 http://dx.doi.org/10.5603/RPOR.a2022.0026 Text en © 2022 Greater Poland Cancer Centre https://creativecommons.org/licenses/by-nc-nd/4.0/This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially
spellingShingle Letter to the Editor
Kovarik, Josef
Kelly, Charles
West, Nick
Drinnan, Michael
Dobrowsky, Werner
Iqbal, Muhammad Shahid
Shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer
title Shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer
title_full Shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer
title_fullStr Shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer
title_full_unstemmed Shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer
title_short Shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer
title_sort shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518781/
https://www.ncbi.nlm.nih.gov/pubmed/36186705
http://dx.doi.org/10.5603/RPOR.a2022.0026
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