Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function

Dysregulation of dopaminergic transmission induced by the HIV-1 transactivator of transcription (Tat) has been implicated as a central factor in the development of HIV-1 associated neurocognitive disorders (HAND). We have demonstrated that the tyrosine470 residue of the human dopamine transporter (h...

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Detalles Bibliográficos
Autores principales: Strauss, Matthew J., Porter, Katherine D., Quizon, Pamela M., Davis, Sarah E., Lin, Steven, Yuan, Yaxia, Martinez-Muniz, Gustavo A., Sun, Wei-Lun, Zhan, Chang-Guo, Zhu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518868/
https://www.ncbi.nlm.nih.gov/pubmed/36170295
http://dx.doi.org/10.1371/journal.pone.0275182

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