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COVID-19 in Africa: Underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact

The epidemic of COVID-19 has shown different developments in Africa compared to the other continents. Three different approaches were used in this study to analyze this situation. In the first part, basic statistics were performed to estimate the contribution of the elderly people to the total numbe...

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Autores principales: Thenon, Nathan, Peyre, Marisa, Huc, Mireille, Touré, Abdoulaye, Roger, François, Mangiarotti, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518880/
https://www.ncbi.nlm.nih.gov/pubmed/36112718
http://dx.doi.org/10.1371/journal.pntd.0010735
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author Thenon, Nathan
Peyre, Marisa
Huc, Mireille
Touré, Abdoulaye
Roger, François
Mangiarotti, Sylvain
author_facet Thenon, Nathan
Peyre, Marisa
Huc, Mireille
Touré, Abdoulaye
Roger, François
Mangiarotti, Sylvain
author_sort Thenon, Nathan
collection PubMed
description The epidemic of COVID-19 has shown different developments in Africa compared to the other continents. Three different approaches were used in this study to analyze this situation. In the first part, basic statistics were performed to estimate the contribution of the elderly people to the total numbers of cases and deaths in comparison to the other continents; Similarly, the health systems capacities were analysed to assess the level of underreporting. In the second part, differential equations were reconstructed from the epidemiological time series of cases and deaths (from the John Hopkins University) to analyse the dynamics of COVID-19 in seventeen countries. In the third part, the time evolution of the contact number was reconstructed since the beginning of the outbreak to investigate the effectiveness of the mitigation strategies. Results were compared to the Oxford stringency index and to the mobility indices of the Google Community Mobility Reports. Compared to Europe, the analyses show that the lower proportion of elderly people in Africa enables to explain the lower total numbers of cases and deaths by a factor of 5.1 on average (from 1.9 to 7.8). It corresponds to a genuine effect. Nevertheless, COVID-19 numbers are effectively largely underestimated in Africa by a factor of 8.5 on average (from 1.7 to 20. and more) due to the weakness of the health systems at country level. Geographically, the models obtained for the dynamics of cases and deaths reveal very diversified dynamics. The dynamics is chaotic in many contexts, including a situation of bistability rarely observed in dynamical systems. Finally, the contact number directly deduced from the epidemiological observations reveals an effective role of the mitigation strategies on the short term. On the long term, control measures have contributed to maintain the epidemic at a low level although the progressive release of the stringency did not produce a clear increase of the contact number. The arrival of the omicron variant is clearly detected and characterised by a quick increase of interpeople contact, for most of the African countries considered in the analysis.
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spelling pubmed-95188802022-09-29 COVID-19 in Africa: Underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact Thenon, Nathan Peyre, Marisa Huc, Mireille Touré, Abdoulaye Roger, François Mangiarotti, Sylvain PLoS Negl Trop Dis Research Article The epidemic of COVID-19 has shown different developments in Africa compared to the other continents. Three different approaches were used in this study to analyze this situation. In the first part, basic statistics were performed to estimate the contribution of the elderly people to the total numbers of cases and deaths in comparison to the other continents; Similarly, the health systems capacities were analysed to assess the level of underreporting. In the second part, differential equations were reconstructed from the epidemiological time series of cases and deaths (from the John Hopkins University) to analyse the dynamics of COVID-19 in seventeen countries. In the third part, the time evolution of the contact number was reconstructed since the beginning of the outbreak to investigate the effectiveness of the mitigation strategies. Results were compared to the Oxford stringency index and to the mobility indices of the Google Community Mobility Reports. Compared to Europe, the analyses show that the lower proportion of elderly people in Africa enables to explain the lower total numbers of cases and deaths by a factor of 5.1 on average (from 1.9 to 7.8). It corresponds to a genuine effect. Nevertheless, COVID-19 numbers are effectively largely underestimated in Africa by a factor of 8.5 on average (from 1.7 to 20. and more) due to the weakness of the health systems at country level. Geographically, the models obtained for the dynamics of cases and deaths reveal very diversified dynamics. The dynamics is chaotic in many contexts, including a situation of bistability rarely observed in dynamical systems. Finally, the contact number directly deduced from the epidemiological observations reveals an effective role of the mitigation strategies on the short term. On the long term, control measures have contributed to maintain the epidemic at a low level although the progressive release of the stringency did not produce a clear increase of the contact number. The arrival of the omicron variant is clearly detected and characterised by a quick increase of interpeople contact, for most of the African countries considered in the analysis. Public Library of Science 2022-09-16 /pmc/articles/PMC9518880/ /pubmed/36112718 http://dx.doi.org/10.1371/journal.pntd.0010735 Text en © 2022 Thenon et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Thenon, Nathan
Peyre, Marisa
Huc, Mireille
Touré, Abdoulaye
Roger, François
Mangiarotti, Sylvain
COVID-19 in Africa: Underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact
title COVID-19 in Africa: Underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact
title_full COVID-19 in Africa: Underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact
title_fullStr COVID-19 in Africa: Underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact
title_full_unstemmed COVID-19 in Africa: Underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact
title_short COVID-19 in Africa: Underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact
title_sort covid-19 in africa: underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518880/
https://www.ncbi.nlm.nih.gov/pubmed/36112718
http://dx.doi.org/10.1371/journal.pntd.0010735
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