Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8(+) T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally,...

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Detalles Bibliográficos
Autores principales: Gargiulo, Ernesto, Viry, Elodie, Moussay, Etienne, Paggetti, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519017/
https://www.ncbi.nlm.nih.gov/pubmed/36185808
http://dx.doi.org/10.1080/2162402X.2022.2127507
Descripción
Sumario:Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8(+) T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.

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