Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8(+) T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally,...

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Detalles Bibliográficos
Autores principales: Gargiulo, Ernesto, Viry, Elodie, Moussay, Etienne, Paggetti, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519017/
https://www.ncbi.nlm.nih.gov/pubmed/36185808
http://dx.doi.org/10.1080/2162402X.2022.2127507
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author Gargiulo, Ernesto
Viry, Elodie
Moussay, Etienne
Paggetti, Jerome
author_facet Gargiulo, Ernesto
Viry, Elodie
Moussay, Etienne
Paggetti, Jerome
author_sort Gargiulo, Ernesto
collection PubMed
description Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8(+) T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.
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spelling pubmed-95190172022-09-29 Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo Gargiulo, Ernesto Viry, Elodie Moussay, Etienne Paggetti, Jerome Oncoimmunology Author’s View Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8(+) T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters. Taylor & Francis 2022-09-27 /pmc/articles/PMC9519017/ /pubmed/36185808 http://dx.doi.org/10.1080/2162402X.2022.2127507 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s View
Gargiulo, Ernesto
Viry, Elodie
Moussay, Etienne
Paggetti, Jerome
Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo
title Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo
title_full Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo
title_fullStr Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo
title_full_unstemmed Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo
title_short Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo
title_sort small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519017/
https://www.ncbi.nlm.nih.gov/pubmed/36185808
http://dx.doi.org/10.1080/2162402X.2022.2127507
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