Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms

Intracellular gap (iGap) formation in liver sinusoidal endothelial cells (LSECs) is caused by the destruction of fenestrae and appears under pathological conditions; nevertheless, their role in metastasis of cancer cells to the liver remained unexplored. We elucidated that hepatotoxin-damaged and fi...

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Detalles Bibliográficos
Autores principales: Huu Hoang, Truong, Sato-Matsubara, Misako, Yuasa, Hideto, Matsubara, Tsutomu, Thuy, Le Thi Thanh, Ikenaga, Hiroko, Phuong, Dong Minh, Hanh, Ngo Vinh, Hieu, Vu Ngoc, Hoang, Dinh Viet, Hai, Hoang, Okina, Yoshinori, Enomoto, Masaru, Tamori, Akihiro, Daikoku, Atsuko, Urushima, Hayato, Ikeda, Kazuo, Dat, Ninh Quoc, Yasui, Yutaka, Shinkawa, Hiroji, Kubo, Shoji, Yamagishi, Ryota, Ohtani, Naoko, Yoshizato, Katsutoshi, Gracia-Sancho, Jordi, Kawada, Norifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519040/
https://www.ncbi.nlm.nih.gov/pubmed/36170363
http://dx.doi.org/10.1126/sciadv.abo5525

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