Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

DNA double-strand breaks (DSBs) are linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence neuroinflammation associated with neurodegeneration. Here, we characterize DSB-bearing neurons from the CK-p25 mouse model of neurodegeneration using single-nucl...

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Detalles Bibliográficos
Autores principales: Welch, Gwyneth M., Boix, Carles A., Schmauch, Eloi, Davila-Velderrain, Jose, Victor, Matheus B., Dileep, Vishnu, Bozzelli, P. Lorenzo, Su, Qiao, Cheng, Jemmie D., Lee, Audrey, Leary, Noelle S., Pfenning, Andreas R., Kellis, Manolis, Tsai, Li-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519048/
https://www.ncbi.nlm.nih.gov/pubmed/36170369
http://dx.doi.org/10.1126/sciadv.abo4662

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