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The Role of Mitochondrial Quality Control in Anthracycline-Induced Cardiotoxicity: From Bench to Bedside

Cardiotoxicity is the major side effect of anthracyclines (doxorubicin, daunorubicin, epirubicin, and idarubicin), though being the most commonly used chemotherapy drugs and the mainstay of therapy in solid and hematological neoplasms. Advances in the field of cardio-oncology have expanded our under...

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Autores principales: Li, Yukun, Lin, Rong, Peng, Xiaodong, Wang, Xuesi, Liu, Xinmeng, Li, Linling, Bai, Rong, Wen, Songnan, Ruan, Yanfei, Chang, Xing, Tang, Ribo, Liu, Nian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519345/
https://www.ncbi.nlm.nih.gov/pubmed/36187332
http://dx.doi.org/10.1155/2022/3659278
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author Li, Yukun
Lin, Rong
Peng, Xiaodong
Wang, Xuesi
Liu, Xinmeng
Li, Linling
Bai, Rong
Wen, Songnan
Ruan, Yanfei
Chang, Xing
Tang, Ribo
Liu, Nian
author_facet Li, Yukun
Lin, Rong
Peng, Xiaodong
Wang, Xuesi
Liu, Xinmeng
Li, Linling
Bai, Rong
Wen, Songnan
Ruan, Yanfei
Chang, Xing
Tang, Ribo
Liu, Nian
author_sort Li, Yukun
collection PubMed
description Cardiotoxicity is the major side effect of anthracyclines (doxorubicin, daunorubicin, epirubicin, and idarubicin), though being the most commonly used chemotherapy drugs and the mainstay of therapy in solid and hematological neoplasms. Advances in the field of cardio-oncology have expanded our understanding of the molecular mechanisms underlying anthracycline-induced cardiotoxicity (AIC). AIC has a complex pathogenesis that includes a variety of aspects such as oxidative stress, autophagy, and inflammation. Emerging evidence has strongly suggested that the loss of mitochondrial quality control (MQC) plays an important role in the progression of AIC. Mitochondria are vital organelles in the cardiomyocytes that serve as the key regulators of reactive oxygen species (ROS) production, energy metabolism, cell death, and calcium buffering. However, as mitochondria are susceptible to damage, the MQC system, including mitochondrial dynamics (fusion/fission), mitophagy, mitochondrial biogenesis, and mitochondrial protein quality control, appears to be crucial in maintaining mitochondrial homeostasis. In this review, we summarize current evidence on the role of MQC in the pathogenesis of AIC and highlight the therapeutic potential of restoring the cardiomyocyte MQC system in the prevention and intervention of AIC.
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spelling pubmed-95193452022-09-29 The Role of Mitochondrial Quality Control in Anthracycline-Induced Cardiotoxicity: From Bench to Bedside Li, Yukun Lin, Rong Peng, Xiaodong Wang, Xuesi Liu, Xinmeng Li, Linling Bai, Rong Wen, Songnan Ruan, Yanfei Chang, Xing Tang, Ribo Liu, Nian Oxid Med Cell Longev Review Article Cardiotoxicity is the major side effect of anthracyclines (doxorubicin, daunorubicin, epirubicin, and idarubicin), though being the most commonly used chemotherapy drugs and the mainstay of therapy in solid and hematological neoplasms. Advances in the field of cardio-oncology have expanded our understanding of the molecular mechanisms underlying anthracycline-induced cardiotoxicity (AIC). AIC has a complex pathogenesis that includes a variety of aspects such as oxidative stress, autophagy, and inflammation. Emerging evidence has strongly suggested that the loss of mitochondrial quality control (MQC) plays an important role in the progression of AIC. Mitochondria are vital organelles in the cardiomyocytes that serve as the key regulators of reactive oxygen species (ROS) production, energy metabolism, cell death, and calcium buffering. However, as mitochondria are susceptible to damage, the MQC system, including mitochondrial dynamics (fusion/fission), mitophagy, mitochondrial biogenesis, and mitochondrial protein quality control, appears to be crucial in maintaining mitochondrial homeostasis. In this review, we summarize current evidence on the role of MQC in the pathogenesis of AIC and highlight the therapeutic potential of restoring the cardiomyocyte MQC system in the prevention and intervention of AIC. Hindawi 2022-09-21 /pmc/articles/PMC9519345/ /pubmed/36187332 http://dx.doi.org/10.1155/2022/3659278 Text en Copyright © 2022 Yukun Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Yukun
Lin, Rong
Peng, Xiaodong
Wang, Xuesi
Liu, Xinmeng
Li, Linling
Bai, Rong
Wen, Songnan
Ruan, Yanfei
Chang, Xing
Tang, Ribo
Liu, Nian
The Role of Mitochondrial Quality Control in Anthracycline-Induced Cardiotoxicity: From Bench to Bedside
title The Role of Mitochondrial Quality Control in Anthracycline-Induced Cardiotoxicity: From Bench to Bedside
title_full The Role of Mitochondrial Quality Control in Anthracycline-Induced Cardiotoxicity: From Bench to Bedside
title_fullStr The Role of Mitochondrial Quality Control in Anthracycline-Induced Cardiotoxicity: From Bench to Bedside
title_full_unstemmed The Role of Mitochondrial Quality Control in Anthracycline-Induced Cardiotoxicity: From Bench to Bedside
title_short The Role of Mitochondrial Quality Control in Anthracycline-Induced Cardiotoxicity: From Bench to Bedside
title_sort role of mitochondrial quality control in anthracycline-induced cardiotoxicity: from bench to bedside
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519345/
https://www.ncbi.nlm.nih.gov/pubmed/36187332
http://dx.doi.org/10.1155/2022/3659278
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