Cargando…

The Emerging Role of Noncoding RNA Regulation of the Ferroptosis in Cardiovascular Diseases

Cardiovascular disease (CVD) is a significant public health issue due to its high prevalence and considerable contribution to the global disease burden. Recent studies suggest that genetic factors, including noncoding RNAs, have an important role in the progression of CVD. Noncoding RNA plays a crit...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Jing, Liu, Xinran, Li, Xiaozhong, Cai, Yuxi, Zhou, Yiwen, Wang, Qiong, Xu, Zhou, Xia, Panpan, Yang, Pingping, Jun, Lei, Yu, Peng, Shi, Ao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519351/
https://www.ncbi.nlm.nih.gov/pubmed/36187333
http://dx.doi.org/10.1155/2022/3595745
_version_ 1784799377675517952
author Zhang, Jing
Liu, Xinran
Li, Xiaozhong
Cai, Yuxi
Zhou, Yiwen
Wang, Qiong
Xu, Zhou
Xia, Panpan
Yang, Pingping
Jun, Lei
Yu, Peng
Shi, Ao
author_facet Zhang, Jing
Liu, Xinran
Li, Xiaozhong
Cai, Yuxi
Zhou, Yiwen
Wang, Qiong
Xu, Zhou
Xia, Panpan
Yang, Pingping
Jun, Lei
Yu, Peng
Shi, Ao
author_sort Zhang, Jing
collection PubMed
description Cardiovascular disease (CVD) is a significant public health issue due to its high prevalence and considerable contribution to the global disease burden. Recent studies suggest that genetic factors, including noncoding RNAs, have an important role in the progression of CVD. Noncoding RNA plays a critical role in genetic programming and gene regulation during development. Ferroptosis is a form of iron-dependent regulated cell death (RCD), which is mainly caused by increased lipid hydroperoxide and redox imbalance. Ferroptosis is essentially different from other forms of RCD in morphology and mechanism, such as apoptosis, autophagic cell death, pyroptosis, and necroptosis. Much evidence suggested ferroptosis is involved in the development of various CVDs, especially in cardiac ischemia/reperfusion injury, heart failure, and aortic dissection. Here, we review the latest findings based on noncoding RNA regulation of ferroptosis and its involvement in the pathogenesis of CVD and related treatments, aimed at providing insights into the impact of noncoding RNA regulation of ferroptosis for CVD.
format Online
Article
Text
id pubmed-9519351
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-95193512022-09-29 The Emerging Role of Noncoding RNA Regulation of the Ferroptosis in Cardiovascular Diseases Zhang, Jing Liu, Xinran Li, Xiaozhong Cai, Yuxi Zhou, Yiwen Wang, Qiong Xu, Zhou Xia, Panpan Yang, Pingping Jun, Lei Yu, Peng Shi, Ao Oxid Med Cell Longev Review Article Cardiovascular disease (CVD) is a significant public health issue due to its high prevalence and considerable contribution to the global disease burden. Recent studies suggest that genetic factors, including noncoding RNAs, have an important role in the progression of CVD. Noncoding RNA plays a critical role in genetic programming and gene regulation during development. Ferroptosis is a form of iron-dependent regulated cell death (RCD), which is mainly caused by increased lipid hydroperoxide and redox imbalance. Ferroptosis is essentially different from other forms of RCD in morphology and mechanism, such as apoptosis, autophagic cell death, pyroptosis, and necroptosis. Much evidence suggested ferroptosis is involved in the development of various CVDs, especially in cardiac ischemia/reperfusion injury, heart failure, and aortic dissection. Here, we review the latest findings based on noncoding RNA regulation of ferroptosis and its involvement in the pathogenesis of CVD and related treatments, aimed at providing insights into the impact of noncoding RNA regulation of ferroptosis for CVD. Hindawi 2022-09-21 /pmc/articles/PMC9519351/ /pubmed/36187333 http://dx.doi.org/10.1155/2022/3595745 Text en Copyright © 2022 Jing Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Jing
Liu, Xinran
Li, Xiaozhong
Cai, Yuxi
Zhou, Yiwen
Wang, Qiong
Xu, Zhou
Xia, Panpan
Yang, Pingping
Jun, Lei
Yu, Peng
Shi, Ao
The Emerging Role of Noncoding RNA Regulation of the Ferroptosis in Cardiovascular Diseases
title The Emerging Role of Noncoding RNA Regulation of the Ferroptosis in Cardiovascular Diseases
title_full The Emerging Role of Noncoding RNA Regulation of the Ferroptosis in Cardiovascular Diseases
title_fullStr The Emerging Role of Noncoding RNA Regulation of the Ferroptosis in Cardiovascular Diseases
title_full_unstemmed The Emerging Role of Noncoding RNA Regulation of the Ferroptosis in Cardiovascular Diseases
title_short The Emerging Role of Noncoding RNA Regulation of the Ferroptosis in Cardiovascular Diseases
title_sort emerging role of noncoding rna regulation of the ferroptosis in cardiovascular diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519351/
https://www.ncbi.nlm.nih.gov/pubmed/36187333
http://dx.doi.org/10.1155/2022/3595745
work_keys_str_mv AT zhangjing theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT liuxinran theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT lixiaozhong theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT caiyuxi theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT zhouyiwen theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT wangqiong theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT xuzhou theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT xiapanpan theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT yangpingping theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT junlei theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT yupeng theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT shiao theemergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT zhangjing emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT liuxinran emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT lixiaozhong emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT caiyuxi emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT zhouyiwen emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT wangqiong emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT xuzhou emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT xiapanpan emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT yangpingping emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT junlei emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT yupeng emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases
AT shiao emergingroleofnoncodingrnaregulationoftheferroptosisincardiovasculardiseases