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Specific PFKFB3 Inhibitor Memorably Ameliorates Intervertebral Disc Degeneration via Inhibiting NF-κB and MAPK Signaling Pathway and Reprogramming of Energy Metabolism of Nucleus Pulposus Cells

Intervertebral disc (IVD) degeneration (IVDD) is a characteristic of the dominating pathological processes of nucleus pulposus (NP) cell senescence, abnormal synthesis and irregular distribution of extracellular matrix (ECM), and tumor necrosis factor-α (TNF-α) induced inflammation. Nowadays, IVD ac...

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Detalles Bibliográficos
Autores principales:	Cao, Xiankun, Wang, Xin, Rong, Kewei, Liu, Kexin, Yang, Xiao, Zhou, Tangjun, Zhang, Pu, Guo, Jiadong, Ma, Hui, Qin, An, Zhao, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519352/ https://www.ncbi.nlm.nih.gov/pubmed/36187335 http://dx.doi.org/10.1155/2022/7548145

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