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The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies

This article presents the international dataset of cases in which the association of Langerhans cell Histiocytosis (LCH) with other malignancies (AM) was documented occurring at any age before, concurrently or after LCH. These data are mostly derived from previously published manuscripts or from com...

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Autores principales: Bagnasco, Francesca, Zimmermann, Stefanie-Yvonne, Egeler, Rudolph Maarten, Nanduri, Vasanta Rao, Cammarata, Bruna, Donadieu, Jean, Lehrnbecher, Thomas, Haupt, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519425/
https://www.ncbi.nlm.nih.gov/pubmed/36188132
http://dx.doi.org/10.1016/j.dib.2022.108604
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author Bagnasco, Francesca
Zimmermann, Stefanie-Yvonne
Egeler, Rudolph Maarten
Nanduri, Vasanta Rao
Cammarata, Bruna
Donadieu, Jean
Lehrnbecher, Thomas
Haupt, Riccardo
author_facet Bagnasco, Francesca
Zimmermann, Stefanie-Yvonne
Egeler, Rudolph Maarten
Nanduri, Vasanta Rao
Cammarata, Bruna
Donadieu, Jean
Lehrnbecher, Thomas
Haupt, Riccardo
author_sort Bagnasco, Francesca
collection PubMed
description This article presents the international dataset of cases in which the association of Langerhans cell Histiocytosis (LCH) with other malignancies (AM) was documented occurring at any age before, concurrently or after LCH. These data are mostly derived from previously published manuscripts or from completed case report forms (CRFs) by Histiocyte Society (HS) members or colleagues. In particular, for each case of LCH-AM, the database reports all the available data about clinical and biologic characteristics of the two tumors, as well about treatment and status at follow-up. The AM were categorized as: i) leukemias [acute lymphoblastic or myeloid leukemia (ALL and AML, respectively), other leukemias] and myeloproliferative disorders; ii) lymphomas [Hodgkin lymphoma (HL) and non-Hodgkin lymphomas (NHL)] and iii) solid tumors. A total of 270 LCH-AM cases were documented, of which 116 (43%) occurred among children. After stratification by age at LCH diagnosis, using 18 years as cut-off between children and adults, we here provide details on the clinical characteristics in terms of LCH system involvement and affected organs, as well on the temporal relationship between the LCH and AM diagnoses, including details on the AM malignancy types. In 19 cases the LCH and the corresponding AM occurred in a different age group. The data set is available for future studies in view of new insights of the genetic or environmental determinants of LCH and/or of treatment related subsequent neoplasms.
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spelling pubmed-95194252022-09-30 The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies Bagnasco, Francesca Zimmermann, Stefanie-Yvonne Egeler, Rudolph Maarten Nanduri, Vasanta Rao Cammarata, Bruna Donadieu, Jean Lehrnbecher, Thomas Haupt, Riccardo Data Brief Data Article This article presents the international dataset of cases in which the association of Langerhans cell Histiocytosis (LCH) with other malignancies (AM) was documented occurring at any age before, concurrently or after LCH. These data are mostly derived from previously published manuscripts or from completed case report forms (CRFs) by Histiocyte Society (HS) members or colleagues. In particular, for each case of LCH-AM, the database reports all the available data about clinical and biologic characteristics of the two tumors, as well about treatment and status at follow-up. The AM were categorized as: i) leukemias [acute lymphoblastic or myeloid leukemia (ALL and AML, respectively), other leukemias] and myeloproliferative disorders; ii) lymphomas [Hodgkin lymphoma (HL) and non-Hodgkin lymphomas (NHL)] and iii) solid tumors. A total of 270 LCH-AM cases were documented, of which 116 (43%) occurred among children. After stratification by age at LCH diagnosis, using 18 years as cut-off between children and adults, we here provide details on the clinical characteristics in terms of LCH system involvement and affected organs, as well on the temporal relationship between the LCH and AM diagnoses, including details on the AM malignancy types. In 19 cases the LCH and the corresponding AM occurred in a different age group. The data set is available for future studies in view of new insights of the genetic or environmental determinants of LCH and/or of treatment related subsequent neoplasms. Elsevier 2022-09-15 /pmc/articles/PMC9519425/ /pubmed/36188132 http://dx.doi.org/10.1016/j.dib.2022.108604 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Bagnasco, Francesca
Zimmermann, Stefanie-Yvonne
Egeler, Rudolph Maarten
Nanduri, Vasanta Rao
Cammarata, Bruna
Donadieu, Jean
Lehrnbecher, Thomas
Haupt, Riccardo
The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies
title The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies
title_full The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies
title_fullStr The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies
title_full_unstemmed The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies
title_short The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies
title_sort international dataset on the association between langerhans cell histiocytosis and other malignancies
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519425/
https://www.ncbi.nlm.nih.gov/pubmed/36188132
http://dx.doi.org/10.1016/j.dib.2022.108604
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