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The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies
This article presents the international dataset of cases in which the association of Langerhans cell Histiocytosis (LCH) with other malignancies (AM) was documented occurring at any age before, concurrently or after LCH. These data are mostly derived from previously published manuscripts or from com...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519425/ https://www.ncbi.nlm.nih.gov/pubmed/36188132 http://dx.doi.org/10.1016/j.dib.2022.108604 |
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author | Bagnasco, Francesca Zimmermann, Stefanie-Yvonne Egeler, Rudolph Maarten Nanduri, Vasanta Rao Cammarata, Bruna Donadieu, Jean Lehrnbecher, Thomas Haupt, Riccardo |
author_facet | Bagnasco, Francesca Zimmermann, Stefanie-Yvonne Egeler, Rudolph Maarten Nanduri, Vasanta Rao Cammarata, Bruna Donadieu, Jean Lehrnbecher, Thomas Haupt, Riccardo |
author_sort | Bagnasco, Francesca |
collection | PubMed |
description | This article presents the international dataset of cases in which the association of Langerhans cell Histiocytosis (LCH) with other malignancies (AM) was documented occurring at any age before, concurrently or after LCH. These data are mostly derived from previously published manuscripts or from completed case report forms (CRFs) by Histiocyte Society (HS) members or colleagues. In particular, for each case of LCH-AM, the database reports all the available data about clinical and biologic characteristics of the two tumors, as well about treatment and status at follow-up. The AM were categorized as: i) leukemias [acute lymphoblastic or myeloid leukemia (ALL and AML, respectively), other leukemias] and myeloproliferative disorders; ii) lymphomas [Hodgkin lymphoma (HL) and non-Hodgkin lymphomas (NHL)] and iii) solid tumors. A total of 270 LCH-AM cases were documented, of which 116 (43%) occurred among children. After stratification by age at LCH diagnosis, using 18 years as cut-off between children and adults, we here provide details on the clinical characteristics in terms of LCH system involvement and affected organs, as well on the temporal relationship between the LCH and AM diagnoses, including details on the AM malignancy types. In 19 cases the LCH and the corresponding AM occurred in a different age group. The data set is available for future studies in view of new insights of the genetic or environmental determinants of LCH and/or of treatment related subsequent neoplasms. |
format | Online Article Text |
id | pubmed-9519425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-95194252022-09-30 The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies Bagnasco, Francesca Zimmermann, Stefanie-Yvonne Egeler, Rudolph Maarten Nanduri, Vasanta Rao Cammarata, Bruna Donadieu, Jean Lehrnbecher, Thomas Haupt, Riccardo Data Brief Data Article This article presents the international dataset of cases in which the association of Langerhans cell Histiocytosis (LCH) with other malignancies (AM) was documented occurring at any age before, concurrently or after LCH. These data are mostly derived from previously published manuscripts or from completed case report forms (CRFs) by Histiocyte Society (HS) members or colleagues. In particular, for each case of LCH-AM, the database reports all the available data about clinical and biologic characteristics of the two tumors, as well about treatment and status at follow-up. The AM were categorized as: i) leukemias [acute lymphoblastic or myeloid leukemia (ALL and AML, respectively), other leukemias] and myeloproliferative disorders; ii) lymphomas [Hodgkin lymphoma (HL) and non-Hodgkin lymphomas (NHL)] and iii) solid tumors. A total of 270 LCH-AM cases were documented, of which 116 (43%) occurred among children. After stratification by age at LCH diagnosis, using 18 years as cut-off between children and adults, we here provide details on the clinical characteristics in terms of LCH system involvement and affected organs, as well on the temporal relationship between the LCH and AM diagnoses, including details on the AM malignancy types. In 19 cases the LCH and the corresponding AM occurred in a different age group. The data set is available for future studies in view of new insights of the genetic or environmental determinants of LCH and/or of treatment related subsequent neoplasms. Elsevier 2022-09-15 /pmc/articles/PMC9519425/ /pubmed/36188132 http://dx.doi.org/10.1016/j.dib.2022.108604 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Data Article Bagnasco, Francesca Zimmermann, Stefanie-Yvonne Egeler, Rudolph Maarten Nanduri, Vasanta Rao Cammarata, Bruna Donadieu, Jean Lehrnbecher, Thomas Haupt, Riccardo The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies |
title | The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies |
title_full | The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies |
title_fullStr | The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies |
title_full_unstemmed | The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies |
title_short | The international dataset on the association between Langerhans Cell Histiocytosis and other malignancies |
title_sort | international dataset on the association between langerhans cell histiocytosis and other malignancies |
topic | Data Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519425/ https://www.ncbi.nlm.nih.gov/pubmed/36188132 http://dx.doi.org/10.1016/j.dib.2022.108604 |
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