Literature-based translation from synthetic lethality screening into therapeutics targets: CD82 is a novel target for KRAS mutation in colon cancer

Synthetic lethality (SL) is an emerging therapeutic paradigm in cancer. We introduced a different approach to prioritize SL gene pairs through literature mining and RAS-mutant high-throughput screening (HTS) data. We matched essential genes from text-mining and mutant genes from the COSMIC and CCLE...

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Detalles Bibliográficos
Autores principales: Yang, Hsih-Te, Chien, Ming-Yu, Chiang, Jung-Hsien, Lin, Peng-Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519430/
https://www.ncbi.nlm.nih.gov/pubmed/36212540
http://dx.doi.org/10.1016/j.csbj.2022.09.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519430/
https://www.ncbi.nlm.nih.gov/pubmed/36212540
http://dx.doi.org/10.1016/j.csbj.2022.09.025

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