Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway

BACKGROUND: Current immunotherapy strategies have contrasting clinical results in human lung cancer patients as small-cell lung cancers (SCLC) often show features of immunological cold tumours. Topoisomerase 1 (TOP1) poisons are effective antitumor drugs with good efficacy against lung cancers. METH...

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Detalles Bibliográficos
Autores principales: Marinello, Jessica, Arleo, Andrea, Russo, Marco, Delcuratolo, Maria, Ciccarelli, Francesca, Pommier, Yves, Capranico, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519573/
https://www.ncbi.nlm.nih.gov/pubmed/35794238
http://dx.doi.org/10.1038/s41416-022-01894-4

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