Multi-context genetic modeling of transcriptional regulation resolves novel disease loci

A majority of the variants identified in genome-wide association studies fall in non-coding regions of the genome, indicating their mechanism of impact is mediated via gene expression. Leveraging this hypothesis, transcriptome-wide association studies (TWAS) have assisted in both the interpretation...

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Detalles Bibliográficos
Autores principales: Thompson, Mike, Gordon, Mary Grace, Lu, Andrew, Tandon, Anchit, Halperin, Eran, Gusev, Alexander, Ye, Chun Jimmie, Balliu, Brunilda, Zaitlen, Noah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519579/
https://www.ncbi.nlm.nih.gov/pubmed/36171194
http://dx.doi.org/10.1038/s41467-022-33212-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519579/
https://www.ncbi.nlm.nih.gov/pubmed/36171194
http://dx.doi.org/10.1038/s41467-022-33212-0

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