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Multi-context genetic modeling of transcriptional regulation resolves novel disease loci

A majority of the variants identified in genome-wide association studies fall in non-coding regions of the genome, indicating their mechanism of impact is mediated via gene expression. Leveraging this hypothesis, transcriptome-wide association studies (TWAS) have assisted in both the interpretation...

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Detalles Bibliográficos
Autores principales:	Thompson, Mike, Gordon, Mary Grace, Lu, Andrew, Tandon, Anchit, Halperin, Eran, Gusev, Alexander, Ye, Chun Jimmie, Balliu, Brunilda, Zaitlen, Noah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519579/ https://www.ncbi.nlm.nih.gov/pubmed/36171194 http://dx.doi.org/10.1038/s41467-022-33212-0

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