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RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11

How the ataxia telangiectasia mutated (ATM) protein kinase, a core protein in DNA damage response, is regulated at post-transcription level remains unclear. Here it is identified that protein Reprimo (RPRM) downregulates ATM protein levels, resulting in impaired DNA repair and enhanced cellular radi...

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Detalles Bibliográficos
Autores principales:	Zhang, Yarui, Ou, Guomin, Ye, Zhujing, Zhou, Zhou, Cao, Qianlin, Li, Mengting, Wang, Jingdong, Cao, Jianping, Yang, Hongying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519624/ https://www.ncbi.nlm.nih.gov/pubmed/36185355 http://dx.doi.org/10.1016/j.isci.2022.105115

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