Cargando…

Recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study

PURPOSE: This study examines individual aggregation of postpartum hemorrhage (PPH), paternal contribution and how offspring birthweight and sex influence recurrence of PPH. Further, we wanted to estimate the proportion of PPH cases attributable to a history of PPH or current birthweight. METHODS: We...

Descripción completa

Detalles Bibliográficos
Autores principales: Linde, Lorentz Erland, Ebbing, Cathrine, Moster, Dag, Kessler, Jörg, Baghestan, Elham, Gissler, Mika, Rasmussen, Svein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519656/
https://www.ncbi.nlm.nih.gov/pubmed/34999924
http://dx.doi.org/10.1007/s00404-021-06374-3
_version_ 1784799448464883712
author Linde, Lorentz Erland
Ebbing, Cathrine
Moster, Dag
Kessler, Jörg
Baghestan, Elham
Gissler, Mika
Rasmussen, Svein
author_facet Linde, Lorentz Erland
Ebbing, Cathrine
Moster, Dag
Kessler, Jörg
Baghestan, Elham
Gissler, Mika
Rasmussen, Svein
author_sort Linde, Lorentz Erland
collection PubMed
description PURPOSE: This study examines individual aggregation of postpartum hemorrhage (PPH), paternal contribution and how offspring birthweight and sex influence recurrence of PPH. Further, we wanted to estimate the proportion of PPH cases attributable to a history of PPH or current birthweight. METHODS: We studied all singleton births in Norway from 1967 to 2017 using data from Norwegian medical and administrational registries. Subsequent births in the parents were linked. Multilevel logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CI) for PPH defined as blood loss > 500 ml, blood loss > 1500 ml, or the need for blood transfusion in parous women. Main exposures were previous PPH, high birthweight, and fetal sex. We calculated adjusted population attributable fractions for previous PPH and current high birthweight. RESULTS: Mothers with a history of PPH had three- and sixfold higher risks of PPH in their second and third deliveries, respectively (adjusted OR 2.9; 95% CI 2.9–3.0 and 6.0; 5.5–6.6). Severe PPH (> 1500 ml) had the highest risk of recurrence. The paternal contribution to recurrence of PPH in deliveries with two different mothers was weak, but significant. If the neonate was male, the risk of PPH was reduced. A history of PPH or birthweight ≥ 4000 g each accounted for 15% of the total number of PPH cases. CONCLUSION: A history of PPH and current birthweight exerted strong effects at both the individual and population levels. Recurrence risk was highest for severe PPH. Occurrence and recurrence were lower in male fetuses, and the paternal influence was weak. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00404-021-06374-3.
format Online
Article
Text
id pubmed-9519656
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-95196562022-09-30 Recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study Linde, Lorentz Erland Ebbing, Cathrine Moster, Dag Kessler, Jörg Baghestan, Elham Gissler, Mika Rasmussen, Svein Arch Gynecol Obstet Original Article PURPOSE: This study examines individual aggregation of postpartum hemorrhage (PPH), paternal contribution and how offspring birthweight and sex influence recurrence of PPH. Further, we wanted to estimate the proportion of PPH cases attributable to a history of PPH or current birthweight. METHODS: We studied all singleton births in Norway from 1967 to 2017 using data from Norwegian medical and administrational registries. Subsequent births in the parents were linked. Multilevel logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CI) for PPH defined as blood loss > 500 ml, blood loss > 1500 ml, or the need for blood transfusion in parous women. Main exposures were previous PPH, high birthweight, and fetal sex. We calculated adjusted population attributable fractions for previous PPH and current high birthweight. RESULTS: Mothers with a history of PPH had three- and sixfold higher risks of PPH in their second and third deliveries, respectively (adjusted OR 2.9; 95% CI 2.9–3.0 and 6.0; 5.5–6.6). Severe PPH (> 1500 ml) had the highest risk of recurrence. The paternal contribution to recurrence of PPH in deliveries with two different mothers was weak, but significant. If the neonate was male, the risk of PPH was reduced. A history of PPH or birthweight ≥ 4000 g each accounted for 15% of the total number of PPH cases. CONCLUSION: A history of PPH and current birthweight exerted strong effects at both the individual and population levels. Recurrence risk was highest for severe PPH. Occurrence and recurrence were lower in male fetuses, and the paternal influence was weak. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00404-021-06374-3. Springer Berlin Heidelberg 2022-01-09 2022 /pmc/articles/PMC9519656/ /pubmed/34999924 http://dx.doi.org/10.1007/s00404-021-06374-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Linde, Lorentz Erland
Ebbing, Cathrine
Moster, Dag
Kessler, Jörg
Baghestan, Elham
Gissler, Mika
Rasmussen, Svein
Recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study
title Recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study
title_full Recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study
title_fullStr Recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study
title_full_unstemmed Recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study
title_short Recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study
title_sort recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519656/
https://www.ncbi.nlm.nih.gov/pubmed/34999924
http://dx.doi.org/10.1007/s00404-021-06374-3
work_keys_str_mv AT lindelorentzerland recurrenceofpostpartumhemorrhagematernalandpaternalcontributionandtheeffectofoffspringbirthweightandsexapopulationbasedcohortstudy
AT ebbingcathrine recurrenceofpostpartumhemorrhagematernalandpaternalcontributionandtheeffectofoffspringbirthweightandsexapopulationbasedcohortstudy
AT mosterdag recurrenceofpostpartumhemorrhagematernalandpaternalcontributionandtheeffectofoffspringbirthweightandsexapopulationbasedcohortstudy
AT kesslerjorg recurrenceofpostpartumhemorrhagematernalandpaternalcontributionandtheeffectofoffspringbirthweightandsexapopulationbasedcohortstudy
AT baghestanelham recurrenceofpostpartumhemorrhagematernalandpaternalcontributionandtheeffectofoffspringbirthweightandsexapopulationbasedcohortstudy
AT gisslermika recurrenceofpostpartumhemorrhagematernalandpaternalcontributionandtheeffectofoffspringbirthweightandsexapopulationbasedcohortstudy
AT rasmussensvein recurrenceofpostpartumhemorrhagematernalandpaternalcontributionandtheeffectofoffspringbirthweightandsexapopulationbasedcohortstudy