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Management and outcome of prenatal absent pulmonary valve syndrome

OBJECTIVE: The purpose of this study was to explore the outcome in fetuses with prenatal diagnosis of absent pulmonary valve syndrome (APVS) on ultrasound imaging. METHODS: A manual web scraping technique was utilized, where MEDLINE and EMBASE were searched along the combination with other relevant...

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Autores principales: Recker, Florian, Weber, Eva C., Strizek, Brigitte, Geipel, Annegret, Berg, Christoph, Gembruch, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519727/
https://www.ncbi.nlm.nih.gov/pubmed/35043273
http://dx.doi.org/10.1007/s00404-022-06397-4
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author Recker, Florian
Weber, Eva C.
Strizek, Brigitte
Geipel, Annegret
Berg, Christoph
Gembruch, Ulrich
author_facet Recker, Florian
Weber, Eva C.
Strizek, Brigitte
Geipel, Annegret
Berg, Christoph
Gembruch, Ulrich
author_sort Recker, Florian
collection PubMed
description OBJECTIVE: The purpose of this study was to explore the outcome in fetuses with prenatal diagnosis of absent pulmonary valve syndrome (APVS) on ultrasound imaging. METHODS: A manual web scraping technique was utilized, where MEDLINE and EMBASE were searched along the combination with other relevant medical subject headings such as “absent pulmonary valve syndrome”, “prenatal APVS” and “APVS/outcome”. The observed outcomes encompassed the rate of chromosomal abnormalities, associations and malformations linked to APVS and fetuses with APVS. A quality assessment of the included studies was also performed. We used meta-analyses of proportions to combine data and fixed or random-effects models according to the heterogeneity of the results. RESULTS: Seven studies including 199 fetuses with APVS were included in the analysis. The median gestational age at referral to the tertiary center was 24.8 weeks. An association to tetralogy of Fallot (TOF) could be seen in 84.4% of all cases. In total 140 out of 199 cases underwent invasive testing, with a total number of 55 abnormal karyotypes [39.3% (95% CI 31.1–47.9%)]. 35.2% of the patients opted for termination of pregnancy (95% CI 28.5–42.3%). CONCLUSION: The analysis underlines the distribution of fetuses with APVS, with 84.4% of cases presenting with TOF/APVS and only 12.6% having APVS/intact ventricular septum (IVS). Larger and more prospective study analyses is now needed, especially focusing on long-term follow-up periods of fetuses and children with APVS. Particularly as the postnatal course shows great variety depending on prenatal diagnosis.
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spelling pubmed-95197272022-09-30 Management and outcome of prenatal absent pulmonary valve syndrome Recker, Florian Weber, Eva C. Strizek, Brigitte Geipel, Annegret Berg, Christoph Gembruch, Ulrich Arch Gynecol Obstet Maternal-Fetal Medicine OBJECTIVE: The purpose of this study was to explore the outcome in fetuses with prenatal diagnosis of absent pulmonary valve syndrome (APVS) on ultrasound imaging. METHODS: A manual web scraping technique was utilized, where MEDLINE and EMBASE were searched along the combination with other relevant medical subject headings such as “absent pulmonary valve syndrome”, “prenatal APVS” and “APVS/outcome”. The observed outcomes encompassed the rate of chromosomal abnormalities, associations and malformations linked to APVS and fetuses with APVS. A quality assessment of the included studies was also performed. We used meta-analyses of proportions to combine data and fixed or random-effects models according to the heterogeneity of the results. RESULTS: Seven studies including 199 fetuses with APVS were included in the analysis. The median gestational age at referral to the tertiary center was 24.8 weeks. An association to tetralogy of Fallot (TOF) could be seen in 84.4% of all cases. In total 140 out of 199 cases underwent invasive testing, with a total number of 55 abnormal karyotypes [39.3% (95% CI 31.1–47.9%)]. 35.2% of the patients opted for termination of pregnancy (95% CI 28.5–42.3%). CONCLUSION: The analysis underlines the distribution of fetuses with APVS, with 84.4% of cases presenting with TOF/APVS and only 12.6% having APVS/intact ventricular septum (IVS). Larger and more prospective study analyses is now needed, especially focusing on long-term follow-up periods of fetuses and children with APVS. Particularly as the postnatal course shows great variety depending on prenatal diagnosis. Springer Berlin Heidelberg 2022-01-18 2022 /pmc/articles/PMC9519727/ /pubmed/35043273 http://dx.doi.org/10.1007/s00404-022-06397-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Maternal-Fetal Medicine
Recker, Florian
Weber, Eva C.
Strizek, Brigitte
Geipel, Annegret
Berg, Christoph
Gembruch, Ulrich
Management and outcome of prenatal absent pulmonary valve syndrome
title Management and outcome of prenatal absent pulmonary valve syndrome
title_full Management and outcome of prenatal absent pulmonary valve syndrome
title_fullStr Management and outcome of prenatal absent pulmonary valve syndrome
title_full_unstemmed Management and outcome of prenatal absent pulmonary valve syndrome
title_short Management and outcome of prenatal absent pulmonary valve syndrome
title_sort management and outcome of prenatal absent pulmonary valve syndrome
topic Maternal-Fetal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519727/
https://www.ncbi.nlm.nih.gov/pubmed/35043273
http://dx.doi.org/10.1007/s00404-022-06397-4
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