The aging immune system in Alzheimer’s and Parkinson’s diseases

The neurodegenerative diseases Alzheimer’s disease (AD) and Parkinson’s disease (PD) both have a myriad of risk factors including genetics, environmental exposures, and lifestyle. However, aging is the strongest risk factor for both diseases. Aging also profoundly influences the immune system, with...

Descripción completa

Detalles Bibliográficos
Autores principales: Heavener, Kelsey S., Bradshaw, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519729/
https://www.ncbi.nlm.nih.gov/pubmed/35505128
http://dx.doi.org/10.1007/s00281-022-00944-6
_version_ 1784799465405677568
author Heavener, Kelsey S.
Bradshaw, Elizabeth M.
author_facet Heavener, Kelsey S.
Bradshaw, Elizabeth M.
author_sort Heavener, Kelsey S.
collection PubMed
description The neurodegenerative diseases Alzheimer’s disease (AD) and Parkinson’s disease (PD) both have a myriad of risk factors including genetics, environmental exposures, and lifestyle. However, aging is the strongest risk factor for both diseases. Aging also profoundly influences the immune system, with immunosenescence perhaps the most prominent outcome. Through genetics, mouse models, and pathology, there is a growing appreciation of the role the immune system plays in neurodegenerative diseases. In this review, we explore the intersection of aging and the immune system in AD and PD.
format Online
Article
Text
id pubmed-9519729
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-95197292022-09-30 The aging immune system in Alzheimer’s and Parkinson’s diseases Heavener, Kelsey S. Bradshaw, Elizabeth M. Semin Immunopathol Review The neurodegenerative diseases Alzheimer’s disease (AD) and Parkinson’s disease (PD) both have a myriad of risk factors including genetics, environmental exposures, and lifestyle. However, aging is the strongest risk factor for both diseases. Aging also profoundly influences the immune system, with immunosenescence perhaps the most prominent outcome. Through genetics, mouse models, and pathology, there is a growing appreciation of the role the immune system plays in neurodegenerative diseases. In this review, we explore the intersection of aging and the immune system in AD and PD. Springer Berlin Heidelberg 2022-05-03 2022 /pmc/articles/PMC9519729/ /pubmed/35505128 http://dx.doi.org/10.1007/s00281-022-00944-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Heavener, Kelsey S.
Bradshaw, Elizabeth M.
The aging immune system in Alzheimer’s and Parkinson’s diseases
title The aging immune system in Alzheimer’s and Parkinson’s diseases
title_full The aging immune system in Alzheimer’s and Parkinson’s diseases
title_fullStr The aging immune system in Alzheimer’s and Parkinson’s diseases
title_full_unstemmed The aging immune system in Alzheimer’s and Parkinson’s diseases
title_short The aging immune system in Alzheimer’s and Parkinson’s diseases
title_sort aging immune system in alzheimer’s and parkinson’s diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519729/
https://www.ncbi.nlm.nih.gov/pubmed/35505128
http://dx.doi.org/10.1007/s00281-022-00944-6
work_keys_str_mv AT heavenerkelseys theagingimmunesysteminalzheimersandparkinsonsdiseases
AT bradshawelizabethm theagingimmunesysteminalzheimersandparkinsonsdiseases
AT heavenerkelseys agingimmunesysteminalzheimersandparkinsonsdiseases
AT bradshawelizabethm agingimmunesysteminalzheimersandparkinsonsdiseases

Ejemplares similares