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Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation
Some kidney donors have diabetes, and little of their natural course of diabetic nephropathy (DN) is known. The aim of this study was to analyze the changes in pathologic lesions in the diabetic donor kidney after KT by performing protocol biopsy two weeks and one year after KT. This retrospective s...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519853/ https://www.ncbi.nlm.nih.gov/pubmed/36187463 http://dx.doi.org/10.3389/ti.2022.10714 |
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author | Lee, Kyo Won Sim, Jongmin Park, Sean S. W. Jeon, Junseok Kim, Gyuri Kim, Min Jung Kwon, Ghee Young Jang, Hye Ryoun Huh, Wooseong Park, Jae Berm |
author_facet | Lee, Kyo Won Sim, Jongmin Park, Sean S. W. Jeon, Junseok Kim, Gyuri Kim, Min Jung Kwon, Ghee Young Jang, Hye Ryoun Huh, Wooseong Park, Jae Berm |
author_sort | Lee, Kyo Won |
collection | PubMed |
description | Some kidney donors have diabetes, and little of their natural course of diabetic nephropathy (DN) is known. The aim of this study was to analyze the changes in pathologic lesions in the diabetic donor kidney after KT by performing protocol biopsy two weeks and one year after KT. This retrospective study included 103 patients who underwent KT, with kidneys from donors with a history of diabetes mellitus (DM). Among them, data of 34 patients who underwent biopsy two weeks and one year after KT were reviewed. Biopsy specimens were reviewed using light microscopy and electron microscopy. Glomerular basement membrane (GBM) thickness at 2 weeks and 1 year was compared. Biopsy showed that DN occurred in 29 of the 34 patients. Only trivial histological changes were observed in 22 patients (64.7%), including 5 patients who did not show DN. At one year after transplantation, there was no change in the DN histologic class in 26 patients (76.5%), and there was no statistically significant difference in the change in GBM thickness. This pattern was observed regardless of the recipient’s DM or glycemic control. With this understanding, clinicians can use kidneys from DM donors with more comfort, thereby reducing the kidney discard rate. |
format | Online Article Text |
id | pubmed-9519853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95198532022-09-30 Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation Lee, Kyo Won Sim, Jongmin Park, Sean S. W. Jeon, Junseok Kim, Gyuri Kim, Min Jung Kwon, Ghee Young Jang, Hye Ryoun Huh, Wooseong Park, Jae Berm Transpl Int Health Archive Some kidney donors have diabetes, and little of their natural course of diabetic nephropathy (DN) is known. The aim of this study was to analyze the changes in pathologic lesions in the diabetic donor kidney after KT by performing protocol biopsy two weeks and one year after KT. This retrospective study included 103 patients who underwent KT, with kidneys from donors with a history of diabetes mellitus (DM). Among them, data of 34 patients who underwent biopsy two weeks and one year after KT were reviewed. Biopsy specimens were reviewed using light microscopy and electron microscopy. Glomerular basement membrane (GBM) thickness at 2 weeks and 1 year was compared. Biopsy showed that DN occurred in 29 of the 34 patients. Only trivial histological changes were observed in 22 patients (64.7%), including 5 patients who did not show DN. At one year after transplantation, there was no change in the DN histologic class in 26 patients (76.5%), and there was no statistically significant difference in the change in GBM thickness. This pattern was observed regardless of the recipient’s DM or glycemic control. With this understanding, clinicians can use kidneys from DM donors with more comfort, thereby reducing the kidney discard rate. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9519853/ /pubmed/36187463 http://dx.doi.org/10.3389/ti.2022.10714 Text en Copyright © 2022 Lee, Sim, Park, Jeon, Kim, Kim, Kwon, Jang, Huh and Park. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Health Archive Lee, Kyo Won Sim, Jongmin Park, Sean S. W. Jeon, Junseok Kim, Gyuri Kim, Min Jung Kwon, Ghee Young Jang, Hye Ryoun Huh, Wooseong Park, Jae Berm Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation |
title | Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation |
title_full | Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation |
title_fullStr | Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation |
title_full_unstemmed | Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation |
title_short | Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation |
title_sort | recoverability of diabetic nephropathy of donor kidney after kidney transplantation |
topic | Health Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519853/ https://www.ncbi.nlm.nih.gov/pubmed/36187463 http://dx.doi.org/10.3389/ti.2022.10714 |
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