Spironolactone alleviates schizophrenia-related reversal learning in Tcf4 transgenic mice subjected to social defeat

Cognitive deficits are a hallmark of schizophrenia, for which no convincing pharmacological treatment option is currently available. Here, we tested spironolactone as a repurposed compound in Tcf4 transgenic mice subjected to psychosocial stress. In this ‘2-hit’ gene by environment mouse (GxE) model...

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Detalles Bibliográficos
Autores principales: Stephan, Marius, Schoeller, Jonathan, Raabe, Florian J., Schmitt, Andrea, Hasan, Alkomiet, Falkai, Peter, Jensen, Niels, Rossner, Moritz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519974/
https://www.ncbi.nlm.nih.gov/pubmed/36171421
http://dx.doi.org/10.1038/s41537-022-00290-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519974/
https://www.ncbi.nlm.nih.gov/pubmed/36171421
http://dx.doi.org/10.1038/s41537-022-00290-4

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