Densely methylated DNA traps Methyl-CpG–binding domain protein 2 but permits free diffusion by Methyl-CpG–binding domain protein 3

The methyl-CpG–binding domain 2 and 3 proteins (MBD2 and MBD3) provide structural and DNA-binding function for the Nucleosome Remodeling and Deacetylase (NuRD) complex. The two proteins form distinct NuRD complexes and show different binding affinity and selectivity for methylated DNA. Previous stud...

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Detalles Bibliográficos
Autores principales: Leighton, Gage O., Irvin, Elizabeth Marie, Kaur, Parminder, Liu, Ming, You, Changjiang, Bhattaram, Dhruv, Piehler, Jacob, Riehn, Robert, Wang, Hong, Pan, Hai, Williams, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520026/
https://www.ncbi.nlm.nih.gov/pubmed/36037972
http://dx.doi.org/10.1016/j.jbc.2022.102428

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