Specific phosphorylation of microtubule-associated protein 2c by extracellular signal–regulated kinase reduces interactions at its Pro-rich regions

Microtubule-associated protein 2 (MAP2) is an important neuronal target of extracellular signal–regulated kinase 2 (ERK2) involved in Raf signaling pathways, but mechanistic details of MAP2 phosphorylation are unclear. Here, we used NMR spectroscopy to quantitatively describe the kinetics of phospho...

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Detalles Bibliográficos
Autores principales: Plucarová, Jitka, Jansen, Séverine, Narasimhan, Subhash, Laníková, Alice, Lewitzky, Marc, Feller, Stephan M., Žídek, Lukáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520037/
https://www.ncbi.nlm.nih.gov/pubmed/35987383
http://dx.doi.org/10.1016/j.jbc.2022.102384

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