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Prevalence and Patterns of EGFR Mutations in Non-small Cell Lung Cancer in the Middle East and North Africa

OBJECTIVES: This study aims to analyze the prevalence and spectrum of epidermal growth factor receptor (EGFR) mutations within the Middle East and North Africa region, compare the findings to other parts of the world, and explore the geographic disparities of EGFR mutations across the region. METHOD...

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Autores principales: Boustany, Youssra, Laraqui, Abdelilah, El Rhaffouli, Hicham, Bajjou, Tahar, El Mchichi, Bouchra, El Anaz, Hicham, Amine, Idriss Lahlou, Chahdi, Hafsa, Oukabli, Mohammed, Souhi, Hicham, Elouazzani, Hanane, Rhorfi, Ismail Abderrahmani, Abid, Ahmed, Mahfoud, Tarik, Tanz, Rachid, Ichou, Mohammed, Ennibi, Khaled, Belkadi, Bouchra, Sekhsokh, Yassine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520149/
http://dx.doi.org/10.1177/10732748221129464
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author Boustany, Youssra
Laraqui, Abdelilah
El Rhaffouli, Hicham
Bajjou, Tahar
El Mchichi, Bouchra
El Anaz, Hicham
Amine, Idriss Lahlou
Chahdi, Hafsa
Oukabli, Mohammed
Souhi, Hicham
Elouazzani, Hanane
Rhorfi, Ismail Abderrahmani
Abid, Ahmed
Mahfoud, Tarik
Tanz, Rachid
Ichou, Mohammed
Ennibi, Khaled
Belkadi, Bouchra
Sekhsokh, Yassine
author_facet Boustany, Youssra
Laraqui, Abdelilah
El Rhaffouli, Hicham
Bajjou, Tahar
El Mchichi, Bouchra
El Anaz, Hicham
Amine, Idriss Lahlou
Chahdi, Hafsa
Oukabli, Mohammed
Souhi, Hicham
Elouazzani, Hanane
Rhorfi, Ismail Abderrahmani
Abid, Ahmed
Mahfoud, Tarik
Tanz, Rachid
Ichou, Mohammed
Ennibi, Khaled
Belkadi, Bouchra
Sekhsokh, Yassine
author_sort Boustany, Youssra
collection PubMed
description OBJECTIVES: This study aims to analyze the prevalence and spectrum of epidermal growth factor receptor (EGFR) mutations within the Middle East and North Africa region, compare the findings to other parts of the world, and explore the geographic disparities of EGFR mutations across the region. METHODS: We conducted a literature search using the terms “[EGFR] AND [mutation] AND [Non-Small Cell Lung Cancer] AND [Middle East OR North Africa]”, using PubMed, Science Direct, Web of science, Embase, Scopus, and Google scholar. RESULTS: A total of 15 eligible studies were included and 6122 patients with non-small cell lung cancer (NSCLC) were analyzed. Male patients were predominant in all of the considered studies, accounting for 70.4%. Of the included patients, 65.6% were smokers and 88.3% had been diagnosed with adenocarcinoma. Overall, EGFR mutations prevalence was 17.2%. In the Middle East, the reported frequency was 16.5%, ranging from 11.3% in Lebanon to 29.7% in the Gulf region. In North Africa, the prevalence of EGFR mutations was 18%, ranging from 17.5% in Egypt to 21.5% in Morocco. The most prevalent mutations were the exon 19 deletions (46.7%) followed by exon 21 substitutions (31.1%). Exon 20 alterations were detected in 10.8% of the analyzed cases, whereas exon 18 mutations were reported in 3.4% of the EGFR-mutated patients. There was 1.1% of patients that had concurrent EGFR mutations. Overall, EGFR mutation prevalence was higher in females [females vs males: 29.7% vs 5.9%, P<.001], non-smokers [non-smokers vs smokers: 31.3% vs 9.6%, P<.001], and patients with adenocarcinoma [adenocarcinoma vs non-adenocarcinoma: 18.8% vs 6.5%, P<.001]. CONCLUSION: EGFR mutation prevalence among the Middle East and North Africa populations is slightly higher than that seen in NSCLC patients of Caucasian ethnicity but is lower than that identified in Asian NSCLC patients. The distribution of these mutations varies considerably throughout the region.
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spelling pubmed-95201492022-09-30 Prevalence and Patterns of EGFR Mutations in Non-small Cell Lung Cancer in the Middle East and North Africa Boustany, Youssra Laraqui, Abdelilah El Rhaffouli, Hicham Bajjou, Tahar El Mchichi, Bouchra El Anaz, Hicham Amine, Idriss Lahlou Chahdi, Hafsa Oukabli, Mohammed Souhi, Hicham Elouazzani, Hanane Rhorfi, Ismail Abderrahmani Abid, Ahmed Mahfoud, Tarik Tanz, Rachid Ichou, Mohammed Ennibi, Khaled Belkadi, Bouchra Sekhsokh, Yassine Cancer Control Review OBJECTIVES: This study aims to analyze the prevalence and spectrum of epidermal growth factor receptor (EGFR) mutations within the Middle East and North Africa region, compare the findings to other parts of the world, and explore the geographic disparities of EGFR mutations across the region. METHODS: We conducted a literature search using the terms “[EGFR] AND [mutation] AND [Non-Small Cell Lung Cancer] AND [Middle East OR North Africa]”, using PubMed, Science Direct, Web of science, Embase, Scopus, and Google scholar. RESULTS: A total of 15 eligible studies were included and 6122 patients with non-small cell lung cancer (NSCLC) were analyzed. Male patients were predominant in all of the considered studies, accounting for 70.4%. Of the included patients, 65.6% were smokers and 88.3% had been diagnosed with adenocarcinoma. Overall, EGFR mutations prevalence was 17.2%. In the Middle East, the reported frequency was 16.5%, ranging from 11.3% in Lebanon to 29.7% in the Gulf region. In North Africa, the prevalence of EGFR mutations was 18%, ranging from 17.5% in Egypt to 21.5% in Morocco. The most prevalent mutations were the exon 19 deletions (46.7%) followed by exon 21 substitutions (31.1%). Exon 20 alterations were detected in 10.8% of the analyzed cases, whereas exon 18 mutations were reported in 3.4% of the EGFR-mutated patients. There was 1.1% of patients that had concurrent EGFR mutations. Overall, EGFR mutation prevalence was higher in females [females vs males: 29.7% vs 5.9%, P<.001], non-smokers [non-smokers vs smokers: 31.3% vs 9.6%, P<.001], and patients with adenocarcinoma [adenocarcinoma vs non-adenocarcinoma: 18.8% vs 6.5%, P<.001]. CONCLUSION: EGFR mutation prevalence among the Middle East and North Africa populations is slightly higher than that seen in NSCLC patients of Caucasian ethnicity but is lower than that identified in Asian NSCLC patients. The distribution of these mutations varies considerably throughout the region. SAGE Publications 2022-09-27 /pmc/articles/PMC9520149/ http://dx.doi.org/10.1177/10732748221129464 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Boustany, Youssra
Laraqui, Abdelilah
El Rhaffouli, Hicham
Bajjou, Tahar
El Mchichi, Bouchra
El Anaz, Hicham
Amine, Idriss Lahlou
Chahdi, Hafsa
Oukabli, Mohammed
Souhi, Hicham
Elouazzani, Hanane
Rhorfi, Ismail Abderrahmani
Abid, Ahmed
Mahfoud, Tarik
Tanz, Rachid
Ichou, Mohammed
Ennibi, Khaled
Belkadi, Bouchra
Sekhsokh, Yassine
Prevalence and Patterns of EGFR Mutations in Non-small Cell Lung Cancer in the Middle East and North Africa
title Prevalence and Patterns of EGFR Mutations in Non-small Cell Lung Cancer in the Middle East and North Africa
title_full Prevalence and Patterns of EGFR Mutations in Non-small Cell Lung Cancer in the Middle East and North Africa
title_fullStr Prevalence and Patterns of EGFR Mutations in Non-small Cell Lung Cancer in the Middle East and North Africa
title_full_unstemmed Prevalence and Patterns of EGFR Mutations in Non-small Cell Lung Cancer in the Middle East and North Africa
title_short Prevalence and Patterns of EGFR Mutations in Non-small Cell Lung Cancer in the Middle East and North Africa
title_sort prevalence and patterns of egfr mutations in non-small cell lung cancer in the middle east and north africa
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520149/
http://dx.doi.org/10.1177/10732748221129464
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