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Urea-based anticancer agents. Exploring 100-years of research with an eye to the future

Suramin was the first urea-based drug to be approved in clinic, and in the following century a number of milestone drugs based on this scaffold were developed. Indeed, urea soon became a privileged scaffold in medicinal chemistry for its capability to establish a peculiar network of drug−target inte...

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Autores principales: Listro, Roberta, Rossino, Giacomo, Piaggi, Federica, Sonekan, Falilat Folasade, Rossi, Daniela, Linciano, Pasquale, Collina, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520293/
https://www.ncbi.nlm.nih.gov/pubmed/36186578
http://dx.doi.org/10.3389/fchem.2022.995351
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author Listro, Roberta
Rossino, Giacomo
Piaggi, Federica
Sonekan, Falilat Folasade
Rossi, Daniela
Linciano, Pasquale
Collina, Simona
author_facet Listro, Roberta
Rossino, Giacomo
Piaggi, Federica
Sonekan, Falilat Folasade
Rossi, Daniela
Linciano, Pasquale
Collina, Simona
author_sort Listro, Roberta
collection PubMed
description Suramin was the first urea-based drug to be approved in clinic, and in the following century a number of milestone drugs based on this scaffold were developed. Indeed, urea soon became a privileged scaffold in medicinal chemistry for its capability to establish a peculiar network of drug−target interactions, for its physicochemical properties that are useful for tuning the druggability of the new chemical entities, and for its structural and synthetic versatility that opened the door to numerous drug design possibilities. In this review, we highlight the relevance of the urea moiety in the medicinal chemistry scenario of anticancer drugs with a special focus on the kinase inhibitors for which this scaffold represented and still represents a pivotal pharmacophoric feature. A general outlook on the approved drugs, recent patents, and current research in this field is herein provided, and the role of the urea moiety in the drug discovery process is discussed form a medicinal chemistry standpoint. We believe that the present review can benefit both academia and pharmaceutical companies’ medicinal chemists to prompt research towards new urea derivatives as anticancer agents.
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spelling pubmed-95202932022-09-30 Urea-based anticancer agents. Exploring 100-years of research with an eye to the future Listro, Roberta Rossino, Giacomo Piaggi, Federica Sonekan, Falilat Folasade Rossi, Daniela Linciano, Pasquale Collina, Simona Front Chem Chemistry Suramin was the first urea-based drug to be approved in clinic, and in the following century a number of milestone drugs based on this scaffold were developed. Indeed, urea soon became a privileged scaffold in medicinal chemistry for its capability to establish a peculiar network of drug−target interactions, for its physicochemical properties that are useful for tuning the druggability of the new chemical entities, and for its structural and synthetic versatility that opened the door to numerous drug design possibilities. In this review, we highlight the relevance of the urea moiety in the medicinal chemistry scenario of anticancer drugs with a special focus on the kinase inhibitors for which this scaffold represented and still represents a pivotal pharmacophoric feature. A general outlook on the approved drugs, recent patents, and current research in this field is herein provided, and the role of the urea moiety in the drug discovery process is discussed form a medicinal chemistry standpoint. We believe that the present review can benefit both academia and pharmaceutical companies’ medicinal chemists to prompt research towards new urea derivatives as anticancer agents. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9520293/ /pubmed/36186578 http://dx.doi.org/10.3389/fchem.2022.995351 Text en Copyright © 2022 Listro, Rossino, Piaggi, Sonekan, Rossi, Linciano and Collina. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Listro, Roberta
Rossino, Giacomo
Piaggi, Federica
Sonekan, Falilat Folasade
Rossi, Daniela
Linciano, Pasquale
Collina, Simona
Urea-based anticancer agents. Exploring 100-years of research with an eye to the future
title Urea-based anticancer agents. Exploring 100-years of research with an eye to the future
title_full Urea-based anticancer agents. Exploring 100-years of research with an eye to the future
title_fullStr Urea-based anticancer agents. Exploring 100-years of research with an eye to the future
title_full_unstemmed Urea-based anticancer agents. Exploring 100-years of research with an eye to the future
title_short Urea-based anticancer agents. Exploring 100-years of research with an eye to the future
title_sort urea-based anticancer agents. exploring 100-years of research with an eye to the future
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520293/
https://www.ncbi.nlm.nih.gov/pubmed/36186578
http://dx.doi.org/10.3389/fchem.2022.995351
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