Cargando…
Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma
Glioma is the most common malignant tumor of the central nervous system and resistance is easily developed to chemotherapy drugs during the treatment process, resulting in high mortality and short survival in glioma patients. Novel therapeutic approaches are urgently needed to improve the therapeuti...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520297/ https://www.ncbi.nlm.nih.gov/pubmed/36185243 http://dx.doi.org/10.3389/fonc.2022.947530 |
_version_ | 1784799591935246336 |
---|---|
author | Zhang, Gaosen Fang, Yi Li, Xiang Zhang, Zhen |
author_facet | Zhang, Gaosen Fang, Yi Li, Xiang Zhang, Zhen |
author_sort | Zhang, Gaosen |
collection | PubMed |
description | Glioma is the most common malignant tumor of the central nervous system and resistance is easily developed to chemotherapy drugs during the treatment process, resulting in high mortality and short survival in glioma patients. Novel therapeutic approaches are urgently needed to improve the therapeutic efficacy of chemotherapeutic drugs and to improve the prognosis of patients with glioma. Ferroptosis is a novel regulatory cell death mechanism that plays a key role in cancer, neurodegenerative diseases, and other diseases. Studies have found that ferroptosis-related regulators are closely related to the survival of patients with glioma, and induction of ferroptosis can improve glioma resistance to chemotherapy drugs. Therefore, induction of tumor cell ferroptosis may be an effective therapeutic strategy for glioma. This review summarizes the relevant mechanisms of ferroptosis, systematically summarizes the key role of ferroptosis in the treatment of glioma and outlines the relationship between ferroptosis-related ncRNAs and the progression of glioma. |
format | Online Article Text |
id | pubmed-9520297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95202972022-09-30 Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma Zhang, Gaosen Fang, Yi Li, Xiang Zhang, Zhen Front Oncol Oncology Glioma is the most common malignant tumor of the central nervous system and resistance is easily developed to chemotherapy drugs during the treatment process, resulting in high mortality and short survival in glioma patients. Novel therapeutic approaches are urgently needed to improve the therapeutic efficacy of chemotherapeutic drugs and to improve the prognosis of patients with glioma. Ferroptosis is a novel regulatory cell death mechanism that plays a key role in cancer, neurodegenerative diseases, and other diseases. Studies have found that ferroptosis-related regulators are closely related to the survival of patients with glioma, and induction of ferroptosis can improve glioma resistance to chemotherapy drugs. Therefore, induction of tumor cell ferroptosis may be an effective therapeutic strategy for glioma. This review summarizes the relevant mechanisms of ferroptosis, systematically summarizes the key role of ferroptosis in the treatment of glioma and outlines the relationship between ferroptosis-related ncRNAs and the progression of glioma. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9520297/ /pubmed/36185243 http://dx.doi.org/10.3389/fonc.2022.947530 Text en Copyright © 2022 Zhang, Fang, Li and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhang, Gaosen Fang, Yi Li, Xiang Zhang, Zhen Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma |
title | Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma |
title_full | Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma |
title_fullStr | Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma |
title_full_unstemmed | Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma |
title_short | Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma |
title_sort | ferroptosis: a novel therapeutic strategy and mechanism of action in glioma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520297/ https://www.ncbi.nlm.nih.gov/pubmed/36185243 http://dx.doi.org/10.3389/fonc.2022.947530 |
work_keys_str_mv | AT zhanggaosen ferroptosisanoveltherapeuticstrategyandmechanismofactioninglioma AT fangyi ferroptosisanoveltherapeuticstrategyandmechanismofactioninglioma AT lixiang ferroptosisanoveltherapeuticstrategyandmechanismofactioninglioma AT zhangzhen ferroptosisanoveltherapeuticstrategyandmechanismofactioninglioma |