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Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome

Pyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis, obesity, diabetes, depression, and Alzheimer’s disease, which usually release pyroptosis-related cytokines due to inflammation. Many studies have demonstrated that aerobic exercise is a good option for decreas...

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Autores principales: Hu, Shujuan, Wan, Xingxia, Li, Xianhui, Wang, Xianwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520335/
https://www.ncbi.nlm.nih.gov/pubmed/36187801
http://dx.doi.org/10.3389/fphys.2022.965366
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author Hu, Shujuan
Wan, Xingxia
Li, Xianhui
Wang, Xianwang
author_facet Hu, Shujuan
Wan, Xingxia
Li, Xianhui
Wang, Xianwang
author_sort Hu, Shujuan
collection PubMed
description Pyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis, obesity, diabetes, depression, and Alzheimer’s disease, which usually release pyroptosis-related cytokines due to inflammation. Many studies have demonstrated that aerobic exercise is a good option for decreasing the release of pyroptosis-related cytokines. However, the molecular mechanisms of aerobic exercise on pyroptosis-related diseases remain unknown. In this review, the effects of aerobic exercise on pyroptosis in endothelial cells, adipocytes and hippocampal cells, and their potential mechanisms are summarized. In endothelial cells, aerobic exercise could inhibit NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis by improving the endothelial function, while reducing vascular inflammation and oxidative stress. In adipocytes, aerobic exercise has been shown to inhibit pyroptosis by ameliorating inflammation and insulin resistance. Moreover, aerobic exercise could restrict pyroptosis by attenuating microglial activation, neuroinflammation, and amyloid-beta deposition in hippocampal cells. In summary, aerobic exercise alleviates the pyroptosis-related diseases by regulating the NLRP3 inflammation si0067naling.
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spelling pubmed-95203352022-09-30 Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome Hu, Shujuan Wan, Xingxia Li, Xianhui Wang, Xianwang Front Physiol Physiology Pyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis, obesity, diabetes, depression, and Alzheimer’s disease, which usually release pyroptosis-related cytokines due to inflammation. Many studies have demonstrated that aerobic exercise is a good option for decreasing the release of pyroptosis-related cytokines. However, the molecular mechanisms of aerobic exercise on pyroptosis-related diseases remain unknown. In this review, the effects of aerobic exercise on pyroptosis in endothelial cells, adipocytes and hippocampal cells, and their potential mechanisms are summarized. In endothelial cells, aerobic exercise could inhibit NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis by improving the endothelial function, while reducing vascular inflammation and oxidative stress. In adipocytes, aerobic exercise has been shown to inhibit pyroptosis by ameliorating inflammation and insulin resistance. Moreover, aerobic exercise could restrict pyroptosis by attenuating microglial activation, neuroinflammation, and amyloid-beta deposition in hippocampal cells. In summary, aerobic exercise alleviates the pyroptosis-related diseases by regulating the NLRP3 inflammation si0067naling. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9520335/ /pubmed/36187801 http://dx.doi.org/10.3389/fphys.2022.965366 Text en Copyright © 2022 Hu, Wan, Li and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Hu, Shujuan
Wan, Xingxia
Li, Xianhui
Wang, Xianwang
Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome
title Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome
title_full Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome
title_fullStr Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome
title_full_unstemmed Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome
title_short Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome
title_sort aerobic exercise alleviates pyroptosis-related diseases by regulating nlrp3 inflammasome
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520335/
https://www.ncbi.nlm.nih.gov/pubmed/36187801
http://dx.doi.org/10.3389/fphys.2022.965366
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