Gefitinib Inhibits Rifampicin-Induced CYP3A4 Gene Expression in Human Hepatocytes

[Image: see text] During multidrug combination chemotherapy, activation of the nuclear receptor and the transcription factor human pregnane xenobiotic receptor (hPXR) has been shown to play a role in the development of chemoresistance. Mechanistically, this could occur due to the cancer drug activat...

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Detalles Bibliográficos
Autores principales: Abbott, Kodye L., Salamat, Julia M., Flannery, Patrick C., Chaudhury, Chloe S., Chandran, Aneesh, Vishveshwara, Saraswathi, Mani, Sridhar, Huang, Jianfeng, Tiwari, Amit K., Pondugula, Satyanarayana R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520547/
https://www.ncbi.nlm.nih.gov/pubmed/36188260
http://dx.doi.org/10.1021/acsomega.2c03270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520547/
https://www.ncbi.nlm.nih.gov/pubmed/36188260
http://dx.doi.org/10.1021/acsomega.2c03270

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