Cargando…
Gefitinib Inhibits Rifampicin-Induced CYP3A4 Gene Expression in Human Hepatocytes
[Image: see text] During multidrug combination chemotherapy, activation of the nuclear receptor and the transcription factor human pregnane xenobiotic receptor (hPXR) has been shown to play a role in the development of chemoresistance. Mechanistically, this could occur due to the cancer drug activat...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520547/ https://www.ncbi.nlm.nih.gov/pubmed/36188260 http://dx.doi.org/10.1021/acsomega.2c03270 |