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Occlusion of two semicircular canals does not disrupt normal hearing in adult mice

Vertigo is a debilitating disease affecting 15–20% of adults worldwide. Vestibular peripheral vertigo is the most common cause of vertigo, often due to Meniere's disease and benign paroxysmal positional vertigo. Although some vertigo symptoms can be controlled by conservative treatment and/or v...

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Autores principales: Wang, Tianying, Liu, Huizhan, He, David Z., Li, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520568/
https://www.ncbi.nlm.nih.gov/pubmed/36188397
http://dx.doi.org/10.3389/fneur.2022.997367
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author Wang, Tianying
Liu, Huizhan
He, David Z.
Li, Yi
author_facet Wang, Tianying
Liu, Huizhan
He, David Z.
Li, Yi
author_sort Wang, Tianying
collection PubMed
description Vertigo is a debilitating disease affecting 15–20% of adults worldwide. Vestibular peripheral vertigo is the most common cause of vertigo, often due to Meniere's disease and benign paroxysmal positional vertigo. Although some vertigo symptoms can be controlled by conservative treatment and/or vestibular rehabilitation therapy, these treatments do not work for some patients. Semicircular canal occlusion surgery has proven to be very effective for these patients with intractable vertigo. However, its application is limited due to concern that the procedure will disrupt normal hearing. In this study, we investigated if occlusion of two semicircular canals would jeopardize auditory function by comparing auditory function and hair cell morphology between the surgical and contralateral ears before and after the surgery in a mouse model. By measuring the auditory brainstem response and distortion product otoacoustic emission 4 weeks post-surgery, we show that auditory function does not significantly change between the surgical and contralateral ears. In addition, confocal imaging has shown no hair cell loss in the cochlear and vestibular sensory epithelia, and scanning electron microscopy also indicates normal stereocilia morphology in the surgical ear. More importantly, the endocochlear potential measured from the surgical ear is not significantly different than that seen in the contralateral ear. Our study suggests that occlusion of two semicircular canals does not disrupt normal hearing in the mouse model, providing a basis to extend the procedure to patients, even those with normal hearing, benefitting more patients with intractable vertigo attacks.
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spelling pubmed-95205682022-09-30 Occlusion of two semicircular canals does not disrupt normal hearing in adult mice Wang, Tianying Liu, Huizhan He, David Z. Li, Yi Front Neurol Neurology Vertigo is a debilitating disease affecting 15–20% of adults worldwide. Vestibular peripheral vertigo is the most common cause of vertigo, often due to Meniere's disease and benign paroxysmal positional vertigo. Although some vertigo symptoms can be controlled by conservative treatment and/or vestibular rehabilitation therapy, these treatments do not work for some patients. Semicircular canal occlusion surgery has proven to be very effective for these patients with intractable vertigo. However, its application is limited due to concern that the procedure will disrupt normal hearing. In this study, we investigated if occlusion of two semicircular canals would jeopardize auditory function by comparing auditory function and hair cell morphology between the surgical and contralateral ears before and after the surgery in a mouse model. By measuring the auditory brainstem response and distortion product otoacoustic emission 4 weeks post-surgery, we show that auditory function does not significantly change between the surgical and contralateral ears. In addition, confocal imaging has shown no hair cell loss in the cochlear and vestibular sensory epithelia, and scanning electron microscopy also indicates normal stereocilia morphology in the surgical ear. More importantly, the endocochlear potential measured from the surgical ear is not significantly different than that seen in the contralateral ear. Our study suggests that occlusion of two semicircular canals does not disrupt normal hearing in the mouse model, providing a basis to extend the procedure to patients, even those with normal hearing, benefitting more patients with intractable vertigo attacks. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9520568/ /pubmed/36188397 http://dx.doi.org/10.3389/fneur.2022.997367 Text en Copyright © 2022 Wang, Liu, He and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Wang, Tianying
Liu, Huizhan
He, David Z.
Li, Yi
Occlusion of two semicircular canals does not disrupt normal hearing in adult mice
title Occlusion of two semicircular canals does not disrupt normal hearing in adult mice
title_full Occlusion of two semicircular canals does not disrupt normal hearing in adult mice
title_fullStr Occlusion of two semicircular canals does not disrupt normal hearing in adult mice
title_full_unstemmed Occlusion of two semicircular canals does not disrupt normal hearing in adult mice
title_short Occlusion of two semicircular canals does not disrupt normal hearing in adult mice
title_sort occlusion of two semicircular canals does not disrupt normal hearing in adult mice
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520568/
https://www.ncbi.nlm.nih.gov/pubmed/36188397
http://dx.doi.org/10.3389/fneur.2022.997367
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