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Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley
Mesona procumbens Hemsley is a plant conventionally processed to provide popular food materials and herbal medicines in Asia. In this study, six triterpene acids, including five new ones (mesonaic acids D-H, 1–5), and one proximadiol-type sesquiterpene (7) were isolated from the methanolic extract o...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520569/ https://www.ncbi.nlm.nih.gov/pubmed/36186589 http://dx.doi.org/10.3389/fchem.2022.1003356 |
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author | Huang, Hung-Tse Lo, I-Wen Liao, Geng-You Lin, Yu-Chi Shen, Yuh-Chiang Huang, Hui-Chi Li, Tsung-Lin Lee, Kung-Ta Kuo, Yao-Haur Liaw, Chia-Ching |
author_facet | Huang, Hung-Tse Lo, I-Wen Liao, Geng-You Lin, Yu-Chi Shen, Yuh-Chiang Huang, Hui-Chi Li, Tsung-Lin Lee, Kung-Ta Kuo, Yao-Haur Liaw, Chia-Ching |
author_sort | Huang, Hung-Tse |
collection | PubMed |
description | Mesona procumbens Hemsley is a plant conventionally processed to provide popular food materials and herbal medicines in Asia. In this study, six triterpene acids, including five new ones (mesonaic acids D-H, 1–5), and one proximadiol-type sesquiterpene (7) were isolated from the methanolic extract of the air-dried M. procumbens. Chemical structures of 1‒7 were established by spectroscopic methods, especially 2D NMR techniques ((1)H–(1)H COSY, HSQC, HMBC, and NOESY) and HRESIMS. Concerning their biological activities, compounds 1, 2, 6, and 7 were examined manifesting high inhibition toward the pro-inflammatory NO production with EC(50) values ranging from 12.88 to 21.21 µM, outrunning the positive control quercetin (24.12 µM). The mesoeudesmol B (7) identified from M. procumbens is the very first example, which exhibited high anti-inflammatory activity diminishing the level of the lipopolysaccharide-induced NO in RAW264.7 macrophage cells, thereby suppressing the secretion of pro-inflammatory cytokines TNF-α and IL-6 and the level of two critical downstream inflammatory mediators iNOS and COX-2. |
format | Online Article Text |
id | pubmed-9520569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95205692022-09-30 Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley Huang, Hung-Tse Lo, I-Wen Liao, Geng-You Lin, Yu-Chi Shen, Yuh-Chiang Huang, Hui-Chi Li, Tsung-Lin Lee, Kung-Ta Kuo, Yao-Haur Liaw, Chia-Ching Front Chem Chemistry Mesona procumbens Hemsley is a plant conventionally processed to provide popular food materials and herbal medicines in Asia. In this study, six triterpene acids, including five new ones (mesonaic acids D-H, 1–5), and one proximadiol-type sesquiterpene (7) were isolated from the methanolic extract of the air-dried M. procumbens. Chemical structures of 1‒7 were established by spectroscopic methods, especially 2D NMR techniques ((1)H–(1)H COSY, HSQC, HMBC, and NOESY) and HRESIMS. Concerning their biological activities, compounds 1, 2, 6, and 7 were examined manifesting high inhibition toward the pro-inflammatory NO production with EC(50) values ranging from 12.88 to 21.21 µM, outrunning the positive control quercetin (24.12 µM). The mesoeudesmol B (7) identified from M. procumbens is the very first example, which exhibited high anti-inflammatory activity diminishing the level of the lipopolysaccharide-induced NO in RAW264.7 macrophage cells, thereby suppressing the secretion of pro-inflammatory cytokines TNF-α and IL-6 and the level of two critical downstream inflammatory mediators iNOS and COX-2. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9520569/ /pubmed/36186589 http://dx.doi.org/10.3389/fchem.2022.1003356 Text en Copyright © 2022 Huang, Lo, Liao, Lin, Shen, Huang, Li, Lee, Kuo and Liaw. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Huang, Hung-Tse Lo, I-Wen Liao, Geng-You Lin, Yu-Chi Shen, Yuh-Chiang Huang, Hui-Chi Li, Tsung-Lin Lee, Kung-Ta Kuo, Yao-Haur Liaw, Chia-Ching Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley |
title | Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley |
title_full | Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley |
title_fullStr | Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley |
title_full_unstemmed | Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley |
title_short | Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley |
title_sort | anti-inflammatory sesquiterpene and triterpene acids from mesona procumbens hemsley |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520569/ https://www.ncbi.nlm.nih.gov/pubmed/36186589 http://dx.doi.org/10.3389/fchem.2022.1003356 |
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