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Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis

The biogenic approach of synthesizing metal nanoparticles is an exciting and interesting research area with a wide range of applications. The present study reports a simple, convenient, low-cost method for synthesizing magnesium oxide nanoparticles (MgONPs) from pumpkin seed extracts and their antic...

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Autores principales: Tabrez, Shams, Khan, Azhar U., Hoque, Mehboob, Suhail, Mohd, Khan, Mohammad Imran, Zughaibi, Torki A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520594/
https://www.ncbi.nlm.nih.gov/pubmed/36186592
http://dx.doi.org/10.3389/fchem.2022.970193
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author Tabrez, Shams
Khan, Azhar U.
Hoque, Mehboob
Suhail, Mohd
Khan, Mohammad Imran
Zughaibi, Torki A.
author_facet Tabrez, Shams
Khan, Azhar U.
Hoque, Mehboob
Suhail, Mohd
Khan, Mohammad Imran
Zughaibi, Torki A.
author_sort Tabrez, Shams
collection PubMed
description The biogenic approach of synthesizing metal nanoparticles is an exciting and interesting research area with a wide range of applications. The present study reports a simple, convenient, low-cost method for synthesizing magnesium oxide nanoparticles (MgONPs) from pumpkin seed extracts and their anticancer efficacy against ovarian teratocarcinoma cell line (PA-1). The characteristic features of biogenic MgONPs were assessed by UV–visible spectrophotometry (UV–vis), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The formation of spherical NPs with an average size of 100 nm was observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Moreover, MgONPs exhibit considerable cytotoxicity with an IC(50) dose of 12.5 μg/ml. A dose-dependent rise in the induction of apoptosis, ROS formation, and inhibition in the migration of PA-1 cells was observed up to 15 μg/ml concentration, reflecting their significant anticancer potential against ovarian teratocarcinoma cell line. However, additional work, especially in different in vitro and in vivo models, is recommended to find out their real potential before this environment-friendly and cost-effective nanoformulation could be exploited for the benefit of humankind.
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spelling pubmed-95205942022-09-30 Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis Tabrez, Shams Khan, Azhar U. Hoque, Mehboob Suhail, Mohd Khan, Mohammad Imran Zughaibi, Torki A. Front Chem Chemistry The biogenic approach of synthesizing metal nanoparticles is an exciting and interesting research area with a wide range of applications. The present study reports a simple, convenient, low-cost method for synthesizing magnesium oxide nanoparticles (MgONPs) from pumpkin seed extracts and their anticancer efficacy against ovarian teratocarcinoma cell line (PA-1). The characteristic features of biogenic MgONPs were assessed by UV–visible spectrophotometry (UV–vis), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The formation of spherical NPs with an average size of 100 nm was observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Moreover, MgONPs exhibit considerable cytotoxicity with an IC(50) dose of 12.5 μg/ml. A dose-dependent rise in the induction of apoptosis, ROS formation, and inhibition in the migration of PA-1 cells was observed up to 15 μg/ml concentration, reflecting their significant anticancer potential against ovarian teratocarcinoma cell line. However, additional work, especially in different in vitro and in vivo models, is recommended to find out their real potential before this environment-friendly and cost-effective nanoformulation could be exploited for the benefit of humankind. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9520594/ /pubmed/36186592 http://dx.doi.org/10.3389/fchem.2022.970193 Text en Copyright © 2022 Tabrez, Khan, Hoque, Suhail, Khan and Zughaibi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Tabrez, Shams
Khan, Azhar U.
Hoque, Mehboob
Suhail, Mohd
Khan, Mohammad Imran
Zughaibi, Torki A.
Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis
title Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis
title_full Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis
title_fullStr Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis
title_full_unstemmed Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis
title_short Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis
title_sort investigating the anticancer efficacy of biogenic synthesized mgonps: an in vitro analysis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520594/
https://www.ncbi.nlm.nih.gov/pubmed/36186592
http://dx.doi.org/10.3389/fchem.2022.970193
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