A water-soluble membrane transporter for biologically relevant cations

Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic...

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Detalles Bibliográficos
Autores principales: Yang, Kylie, Boles, Jessica E., White, Lisa J., Hilton, Kira L. F., Lai, Hin Yuk, Long, Yifan, Hiscock, Jennifer R., Haynes, Cally J. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520675/
https://www.ncbi.nlm.nih.gov/pubmed/36320246
http://dx.doi.org/10.1039/d2ra05314d
Descripción
Sumario:Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.

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