A water-soluble membrane transporter for biologically relevant cations

Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic...

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Detalles Bibliográficos
Autores principales: Yang, Kylie, Boles, Jessica E., White, Lisa J., Hilton, Kira L. F., Lai, Hin Yuk, Long, Yifan, Hiscock, Jennifer R., Haynes, Cally J. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520675/
https://www.ncbi.nlm.nih.gov/pubmed/36320246
http://dx.doi.org/10.1039/d2ra05314d
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author Yang, Kylie
Boles, Jessica E.
White, Lisa J.
Hilton, Kira L. F.
Lai, Hin Yuk
Long, Yifan
Hiscock, Jennifer R.
Haynes, Cally J. E.
author_facet Yang, Kylie
Boles, Jessica E.
White, Lisa J.
Hilton, Kira L. F.
Lai, Hin Yuk
Long, Yifan
Hiscock, Jennifer R.
Haynes, Cally J. E.
author_sort Yang, Kylie
collection PubMed
description Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.
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spelling pubmed-95206752022-10-31 A water-soluble membrane transporter for biologically relevant cations Yang, Kylie Boles, Jessica E. White, Lisa J. Hilton, Kira L. F. Lai, Hin Yuk Long, Yifan Hiscock, Jennifer R. Haynes, Cally J. E. RSC Adv Chemistry Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments. The Royal Society of Chemistry 2022-09-29 /pmc/articles/PMC9520675/ /pubmed/36320246 http://dx.doi.org/10.1039/d2ra05314d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Yang, Kylie
Boles, Jessica E.
White, Lisa J.
Hilton, Kira L. F.
Lai, Hin Yuk
Long, Yifan
Hiscock, Jennifer R.
Haynes, Cally J. E.
A water-soluble membrane transporter for biologically relevant cations
title A water-soluble membrane transporter for biologically relevant cations
title_full A water-soluble membrane transporter for biologically relevant cations
title_fullStr A water-soluble membrane transporter for biologically relevant cations
title_full_unstemmed A water-soluble membrane transporter for biologically relevant cations
title_short A water-soluble membrane transporter for biologically relevant cations
title_sort water-soluble membrane transporter for biologically relevant cations
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520675/
https://www.ncbi.nlm.nih.gov/pubmed/36320246
http://dx.doi.org/10.1039/d2ra05314d
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