Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R

[Image: see text] Ornithine decarboxylase (ODC) is a rate-limiting enzyme for the synthesis of polyamines (PAs). PAs are required for proliferation, and increased ODC activity is associated with cancer and neural over-proliferation. ODC levels and activity are therefore tightly regulated, including...

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Autores principales: Zhou, X. Edward, Schultz, Chad R., Suino Powell, Kelly, Henrickson, Amy, Lamp, Jared, Brunzelle, Joseph S., Demeler, Borries, Vega, Irving E., Bachmann, André S., Melcher, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520691/
https://www.ncbi.nlm.nih.gov/pubmed/36188294
http://dx.doi.org/10.1021/acsomega.2c04702

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